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1 : 1 mixture (racemate)
Systematic (IUPAC) name
(RS)-2-(dimethylamino)-5-phenyl-1,3-oxazol-4(5H)-one
Identifiers
CAS number 655-05-0
ATC code none
PubChem 12602
Chemical data
Formula C11H12N2O2 
Mol. mass 204.225 g/mol
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status Prescription only
Routes Oral

Thozalinone (Stimsen) is a psychostimulant that has been used as an antidepressant in Europe.[1][2][3][4] It has also been trialed as an anorectic.[5] Thozalinone likely acts via inducing the release of norepinephrine and dopamine as with its analogues pemoline and aminorex.[1][6][7]

See also

References

  1. ^ a b Greenblatt EN, Osterberg AC (July 1965). "Some pharmacologic properties of thozalinone, a new excitant". Toxicology and Applied Pharmacology 7 (4): 566–78. PMID 4378772. 
  2. ^ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8. http://books.google.com/books?id=C3Uo1co4Wv0C&lpg=PA2539&dq=thozalinone&as_brr=3&pg=PA2539#v=onepage&q=&f=false. 
  3. ^ Merck index on CD-ROM: Windows. London: Chapman & Hall EPD. 1998. ISBN 0-412-82910-X. 
  4. ^ Gallant DM, Bishop MP, Scrignar CB, Hornsby L, Moore B, Inturrisi BB (December 1966). "A double-blind study of thozalinone (C1 39,808) in depressed outpatients". Current Therapeutic Research, Clinical and Experimental 8 (12): 621–2. PMID 4962734. 
  5. ^ Leite AC, Liepen LL, Costa VP (September 1971). "[Clinical trial of Stimsem Thozalinone in the treatment of obese patients]" (in Portuguese). Revista Brasileira De Medicina 28 (9): 475–8. PMID 5139648. 
  6. ^ Yen-Koo HC, Balazs T (1980). "Detection of dopaminergic supersensitivity induced by neuroleptic drugs in mice". Drug and Chemical Toxicology 3 (2): 237–47. doi:10.3109/01480548009108286. PMID 6112126. http://informahealthcare.com/doi/abs/10.3109/01480548009108286. 
  7. ^ Yen-Koo HC, Davis DA, Balazs T (1985). "Inhibition of dopaminergic agonist-induced gnawing behavior by neuroleptic drugs in mice". Drug and Chemical Toxicology 8 (6): 495–502. doi:10.3109/01480548509041072. PMID 2868876. http://informahealthcare.com/doi/abs/10.3109/01480548509041072. 
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