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Thygeson's superficial punctate keratopathy
Classification and external resources

Thygeson's keratitis. Note the slightly elevated, grayish-white subepithelial opacities.
ICD-10 H16.1
ICD-9 370.21
DiseasesDB 31288
eMedicine article/1197335

Thygeson's superficial punctate keratopathy (TSPK; also Thygeson Superficial Punctate Keratitis) is a disease of the eyes. The causes of TSPK are not currently known, but details of the disease were first published in the Journal of the American Medical Association in 1950 by Phillips Thygeson - after whom it is named.[1]



A patient with TSPK may complain of blurred vision, watery eyes, a sensation of having a foreign body stuck in the eye and sensitivity to bright light. On inspection with a slit lamp, tiny lumps can be found on the cornea of the eye. These lumps can be more easily seen after applying fluorescein or rose bengal dye eye-drops. The lumps appear to be randomly positioned on the cornea and they may appear and disappear over a period of time (with or without treatment).

TSPK may affect one or both eyes. When both eyes are affected, the tiny lumps found on the cornea may differ in number between eyes. The severity of the symptoms often vary during the course of the disease. The disease may appear to go into remission, only to later reappear after months or years.


The causes of TSPK are not currently known.


Same cornea as in the disease template on the upper right part of the page. Full resolution of opacities. From Hasanreisoglu and Avisar, 2008.[2]

There are a number of different treatments to deal with TSPK. Symptoms may disappear without treatment, but treatment may help increase time to and success of remission.

See also


External links

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