The Full Wiki

More info on Thyroid hormone receptor

Thyroid hormone receptor: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
Identifiers
Symbol THRA
Alt. symbols THRA1, THRA2, ERBA1
Entrez 7067
HUGO 11796
OMIM 190120
RefSeq NM_199334
UniProt P10827
Other data
Locus Chr. 17 q11.2-17q12
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
Identifiers
Symbol THRB
Alt. symbols ERBA2
Entrez 7068
HUGO 11799
OMIM 190160
RefSeq NM_000461
UniProt P10828
Other data
Locus Chr. 3 p24.1-p22

The thyroid hormone receptor[1] is a type of nuclear receptor that is activated by binding thyroid hormone.[2]

Contents

Function

Amongst the most important functions of thyroid hormone receptors are regulation of metabolism and heart rate.[3][4] In addition, they play critical roles in the development of organisms.[5]

Isoforms

There are three forms of the thyroid hormone receptor designated alpha-1, beta-1 and beta-2 that are able to bind thyroid hormone. There are two TR-alpha receptor splice variants encoded by the THRA gene and two TR-beta isoform splice variants encoded by the THRB gene:[2]

  • TR-α1 (widely expressed and especially high expression in cardiac and skeletal muscles)
  • TR-α2 (homologous with viral oncogen c-erb-A, also widely expressed but unable to bind hormone)
  • TR-β1 (predominately expressed in brain, liver and kidney)
  • TR-β2 (expression primarily limited to the hypothalamus and pituitary)

Disease linkage

Certain mutations in the thyroid hormone receptor are associated with thyroid hormone resistance.[6]

References

  1. ^ Spurr NK, Solomon E, Jansson M, Sheer D, Goodfellow PN, Bodmer WF, Vennstrom B (1984). "Chromosomal localisation of the human homologues to the oncogenes erbA and B". EMBO J. 3 (1): 159–63. PMID 6323162. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=6323162.  
  2. ^ a b Flamant F, Baxter JD, Forrest D, Refetoff S, Samuels H, Scanlan TS, Vennstrom B, Samarut J (2006). "International Union of Pharmacology. LIX. The pharmacology and classification of the nuclear receptor superfamily: thyroid hormone receptors". Pharmacol Rev 58 (4): 705–11. doi:10.1124/pr.58.4.3. PMID 17132849.  
  3. ^ Yen PM (2001). "Physiological and molecular basis of thyroid hormone action". Physiol Rev 81 (3): 1097–142. PMID 11427693. http://physrev.physiology.org/cgi/content/abstract/81/3/1097.  
  4. ^ Harvey CB, Williams GR (2002). "Mechanism of thyroid hormone action". Thyroid (journal) 12 (6): 441–6. doi:10.1089/105072502760143791. PMID 12165104.  
  5. ^ Brent GA (2000). "Tissue-specific actions of thyroid hormone: insights from animal models". Rev Endocr Metab Disord 1 (1-2): 27–33. doi:10.1023/A:1010056202122. PMID 11704989.  
  6. ^ Olateju TO, Vanderpump MP (2006). "Thyroid hormone resistance". Ann Clin Biochem 43 (Pt 6): 431–40. doi:10.1258/000456306778904678. PMID 17132274.  

External links

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message