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Thyroid hormone receptor alpha: Wikis


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Thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)

PDB rendering based on 1nav.
Available structures
1nav, 2h77, 2h79
Symbols THRA; AR7; EAR7; ERB-T-1; ERBA; ERBA1; MGC000261; MGC43240; NR1A1; THRA1; THRA2; c-ERBA-1
External IDs OMIM190120 MGI98742 HomoloGene37747 GeneCards: THRA Gene
RNA expression pattern
PBB GE THRA 35846 at tn.png
PBB GE THRA 204100 at tn.png
More reference expression data
Species Human Mouse
Entrez 7067 21833
Ensembl ENSG00000126351 ENSMUSG00000058756
UniProt P10827 Q80Y90
RefSeq (mRNA) NM_003250 XM_994382
RefSeq (protein) NP_003241 XP_999476
Location (UCSC) Chr 17:
35.47 - 35.5 Mb
Chr 11:
98.56 - 98.59 Mb
PubMed search [1] [2]

Thyroid hormone receptor alpha (TR-alpha) (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian), also known as NR1A1 (nuclear receptor subfamily 1, group A, member 1), is nuclear receptor protein encoded by the THRA gene.[1]

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[1]


THR1 has been shown to interact with NCOA6,[2][3] MED16,[4] MEF2A,[5] TRIP11,[6] MED1,[7] ITGB3BP,[8][9] MED6,[4] COPS2,[10] EP300,[5] MED12[4] and UBC.[11]


  1. ^ a b "Entrez Gene: THRA thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)".  
  2. ^ Lee, S K; Anzick S L, Choi J E, Bubendorf L, Guan X Y, Jung Y K, Kallioniemi O P, Kononen J, Trent J M, Azorsa D, Jhun B H, Cheong J H, Lee Y C, Meltzer P S, Lee J W (Nov. 1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". J. Biol. Chem. (UNITED STATES) 274 (48): 34283–93. ISSN 0021-9258. PMID 10567404.  
  3. ^ Lee, S K; Na S Y, Jung S Y, Choi J E, Jhun B H, Cheong J, Meltzer P S, Lee Y C, Lee J W (Jun. 2000). "Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2". Mol. Endocrinol. (UNITED STATES) 14 (6): 915–25. ISSN 0888-8809. PMID 10847592.  
  4. ^ a b c Ito, M; Yuan C X, Malik S, Gu W, Fondell J D, Yamamura S, Fu Z Y, Zhang X, Qin J, Roeder R G (Mar. 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell (UNITED STATES) 3 (3): 361–70. ISSN 1097-2765. PMID 10198638.  
  5. ^ a b De Luca, Antonio; Severino Anna, De Paolis Paola, Cottone Giuliano, De Luca Luca, De Falco Maria, Porcellini Antonio, Volpe Massimo, Condorelli Gianluigi (Feb. 2003). "p300/cAMP-response-element-binding-protein ('CREB')-binding protein (CBP) modulates co-operation between myocyte enhancer factor 2A (MEF2A) and thyroid hormone receptor-retinoid X receptor". Biochem. J. (England) 369 (Pt 3): 477–84. doi:10.1042/BJ20020057. ISSN 0264-6021. PMID 12371907.  
  6. ^ Chang, K H; Chen Y, Chen T T, Chou W H, Chen P L, Ma Y Y, Yang-Feng T L, Leng X, Tsai M J, O'Malley B W, Lee W H (Aug. 1997). "A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (17): 9040–5. ISSN 0027-8424. PMID 9256431.  
  7. ^ Yuan, C X; Ito M, Fondell J D, Fu Z Y, Roeder R G (Jul. 1998). "The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (14): 7939–44. ISSN 0027-8424. PMID 9653119.  
  8. ^ Li, D; Wang F, Samuels H H (Dec. 2001). "Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation". Mol. Cell. Biol. (United States) 21 (24): 8371–84. doi:10.1128/MCB.21.24.8371-8384.2001. ISSN 0270-7306. PMID 11713274.  
  9. ^ Li, D; Desai-Yajnik V, Lo E, Schapira M, Abagyan R, Samuels H H (Oct. 1999). "NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptors". Mol. Cell. Biol. (UNITED STATES) 19 (10): 7191–202. ISSN 0270-7306. PMID 10490654.  
  10. ^ Dressel, U; Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum S P, Renkawitz R, Baniahmad A (May. 1999). "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily". Mol. Cell. Biol. (UNITED STATES) 19 (5): 3383–94. ISSN 0270-7306. PMID 10207062.  
  11. ^ Tan, Fengwei; Lu Lifang, Cai Yun, Wang Jinglan, Xie Yunfei, Wang Lin, Gong Yanhua, Xu Bing-E, Wu Jun, Luo Ying, Qiang Boqin, Yuan Jiangang, Sun Xiaoqing, Peng Xiaozhong (Jul. 2008). "Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells". Proteomics (Germany) 8 (14): 2885–96. doi:10.1002/pmic.200700887. PMID 18655026.  

Further reading

  • Forrest D, Reh TA, Rüsch A (2002). "Neurodevelopmental control by thyroid hormone receptors.". Curr. Opin. Neurobiol. 12 (1): 49–56. doi:10.1016/S0959-4388(02)00289-1. PMID 11861164.  
  • Sakurai A, Bell GI, DeGroot LJ (1993). "Dinucleotide repeat polymorphism in the human thyroid hormone receptor alpha gene (THRA1) on chromosome 17.". Hum. Mol. Genet. 1 (7): 553. doi:10.1093/hmg/1.7.553-a. PMID 1307263.  
  • Berrodin TJ, Marks MS, Ozato K, et al. (1992). "Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein.". Mol. Endocrinol. 6 (9): 1468–78. doi:10.1210/me.6.9.1468. PMID 1331778.  
  • Schmidt ED, Schmidt ED, van der Gaag R, et al. (1992). "Distribution of the nuclear thyroid-hormone receptor in extraocular and skeletal muscles.". J. Endocrinol. 133 (1): 67–74. doi:10.1677/joe.0.1330067. PMID 1517709.  
  • Yen PM, Sunday ME, Darling DS, Chin WW (1992). "Isoform-specific thyroid hormone receptor antibodies detect multiple thyroid hormone receptors in rat and human pituitaries.". Endocrinology 130 (3): 1539–46. doi:10.1210/en.130.3.1539. PMID 1537303.  
  • Laudet V, Begue A, Henry-Duthoit C, et al. (1991). "Genomic organization of the human thyroid hormone receptor alpha (c-erbA-1) gene.". Nucleic Acids Res. 19 (5): 1105–12. doi:10.1093/nar/19.5.1105. PMID 1850510.  
  • Nakai A, Sakurai A, Bell GI, DeGroot LJ (1989). "Characterization of a third human thyroid hormone receptor coexpressed with other thyroid hormone receptors in several tissues.". Mol. Endocrinol. 2 (11): 1087–92. doi:10.1210/mend-2-11-1087. PMID 2464749.  
  • Miyajima N, Horiuchi R, Shibuya Y, et al. (1989). "Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus.". Cell 57 (1): 31–9. doi:10.1016/0092-8674(89)90169-4. PMID 2539258.  
  • Sakurai A, Nakai A, DeGroot LJ (1989). "Expression of three forms of thyroid hormone receptor in human tissues.". Mol. Endocrinol. 3 (2): 392–9. doi:10.1210/mend-3-2-392. PMID 2710139.  
  • Sap J, Muñoz A, Damm K, et al. (1987). "The c-erb-A protein is a high-affinity receptor for thyroid hormone.". Nature 324 (6098): 635–40. doi:10.1038/324635a0. PMID 2879242.  
  • Nakai A, Seino S, Sakurai A, et al. (1988). "Characterization of a thyroid hormone receptor expressed in human kidney and other tissues.". Proc. Natl. Acad. Sci. U.S.A. 85 (8): 2781–5. doi:10.1073/pnas.85.8.2781. PMID 3357890.  
  • Mitelman F, Manolov G, Manolova Y, et al. (1986). "High resolution chromosome analysis of constitutional and acquired t(15;17) maps c-erbA to subband 17q11.2.". Cancer Genet. Cytogenet. 22 (2): 95–8. doi:10.1016/0165-4608(86)90168-8. PMID 3458521.  
  • Benbrook D, Pfahl M (1987). "A novel thyroid hormone receptor encoded by a cDNA clone from a human testis library.". Science 238 (4828): 788–91. doi:10.1126/science.3672126. PMID 3672126.  
  • Pfahl M, Benbrook D (1988). "Nucleotide sequence of cDNA encoding a novel human thyroid hormone receptor.". Nucleic Acids Res. 15 (22): 9613. doi:10.1093/nar/15.22.9613. PMID 3684612.  
  • Spurr NK, Solomon E, Jansson M, et al. (1984). "Chromosomal localisation of the human homologues to the oncogenes erbA and B.". Embo J. 3 (1): 159–63. PMID 6323162.  
  • Dayton AI, Selden JR, Laws G, et al. (1984). "A human c-erbA oncogene homologue is closely proximal to the chromosome 17 breakpoint in acute promyelocytic leukemia.". Proc. Natl. Acad. Sci. U.S.A. 81 (14): 4495–9. doi:10.1073/pnas.81.14.4495. PMID 6589608.  
  • Chen JD, Evans RM (1995). "A transcriptional co-repressor that interacts with nuclear hormone receptors.". Nature 377 (6548): 454–7. doi:10.1038/377454a0. PMID 7566127.  
  • Desai-Yajnik V, Hadzic E, Modlinger P, et al. (1995). "Interactions of thyroid hormone receptor with the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and the HIV-1 Tat transactivator.". J. Virol. 69 (8): 5103–12. PMID 7609079.  
  • Lee JW, Choi HS, Gyuris J, et al. (1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.". Mol. Endocrinol. 9 (2): 243–54. doi:10.1210/me.9.2.243. PMID 7776974.  
  • Desai-Yajnik V, Samuels HH (1994). "Regulation of the human immunodeficiency virus type 1 long terminal repeat: interactions of thyroid hormone receptor with retinoid-X receptor, nuclear factor kappa B, Sp1, and Tat.". Trans. Assoc. Am. Physicians 106: 13–32. PMID 8036737.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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