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Thyrotropin-releasing hormone receptor
Symbols TRHR; MGC141920
External IDs OMIM188545 MGI98824 HomoloGene20707 IUPHAR: TRH1 GeneCards: TRHR Gene
RNA expression pattern
PBB GE TRHR 211438 at tn.png
More reference expression data
Species Human Mouse
Entrez 7201 22045
Ensembl ENSG00000174417 ENSMUSG00000038760
UniProt P34981 Q32MS1
RefSeq (mRNA) NM_003301 NM_013696
RefSeq (protein) NP_003292 NP_038724
Location (UCSC) Chr 8:
110.17 - 110.2 Mb
Chr 15:
44.03 - 44.06 Mb
PubMed search [1] [2]

The thyrotropin-releasing hormone receptor (TRHR) is a G protein-coupled receptor which binds the tripeptide thyrotropin releasing hormone.[1][2] The TRHR are found in the brain and when bound by TRH result act through phospholipase C to increase intracellular inositol triphosphate.


  1. ^ Yamada M, Monden T, Konaka S, Mori M (1993). "Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8". Somat. Cell Mol. Genet. 19 (6): 577–80. doi:10.1007/BF01233384. PMID 8128317.  
  2. ^ Gershengorn MC (1993). "Thyrotropin-releasing hormone receptor: cloning and regulation of its expression". Recent Prog. Horm. Res. 48: 341–63. PMID 8382829.  

Further reading

  • Short RE, James LF, Panter KE, et al. (1993). "Effects of feeding ponderosa pine needles during pregnancy: comparative studies with bison, cattle, goats, and sheep.". J. Anim. Sci. 70 (11): 3498–504. PMID 1459912.  
  • Yamada M, Iwasaki T, Satoh T, et al. (1996). "Activation of the thyrotropin-releasing hormone (TRH) receptor by a direct precursor of TRH, TRH-Gly.". Neurosci. Lett. 196 (1-2): 109–12. doi:10.1016/0304-3940(95)11861-P. PMID 7501234.  
  • Hinuma S, Hosoya M, Ogi K, et al. (1994). "Molecular cloning and functional expression of a human thyrotropin-releasing hormone (TRH) receptor gene.". Biochim. Biophys. Acta 1219 (2): 251–9. PMID 7918619.  
  • Morrison N, Duthie SM, Boyd E, et al. (1994). "Assignment of the gene encoding the human thyrotropin-releasing hormone receptor to 8q23 by fluorescence in situ hybridization.". Hum. Genet. 93 (6): 716–8. PMID 8005602.  
  • Yamada M, Monden T, Konaka S, Mori M (1994). "Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8.". Somat. Cell Mol. Genet. 19 (6): 577–80. doi:10.1007/BF01233384. PMID 8128317.  
  • Duthie SM, Taylor PL, Anderson L, et al. (1994). "Cloning and functional characterisation of the human TRH receptor.". Mol. Cell. Endocrinol. 95 (1-2): R11–5. doi:10.1016/0303-7207(93)90043-J. PMID 8243797.  
  • Matre V, Karlsen HE, Wright MS, et al. (1993). "Molecular cloning of a functional human thyrotropin-releasing hormone receptor.". Biochem. Biophys. Res. Commun. 195 (1): 179–85. doi:10.1006/bbrc.1993.2027. PMID 8395824.  
  • Yamada M, Monden T, Satoh T, et al. (1993). "Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene.". Biochem. Biophys. Res. Commun. 195 (2): 737–45. doi:10.1006/bbrc.1993.2107. PMID 8396925.  
  • Iwasaki T, Yamada M, Satoh T, et al. (1996). "Genomic organization and promoter function of the human thyrotropin-releasing hormone receptor gene.". J. Biol. Chem. 271 (36): 22183–8. doi:10.1074/jbc.271.36.22183. PMID 8703031.  
  • Cook JV, McGregor A, Lee T, et al. (1996). "A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor.". Endocrinology 137 (7): 2851–8. doi:10.1210/en.137.7.2851. PMID 8770906.  
  • Collu R, Tang J, Castagné J, et al. (1997). "A novel mechanism for isolated central hypothyroidism: inactivating mutations in the thyrotropin-releasing hormone receptor gene.". J. Clin. Endocrinol. Metab. 82 (5): 1561–5. doi:10.1210/jc.82.5.1561. PMID 9141550.  
  • Petrou C, Tashjian AH (1999). "The thyrotropin-releasing hormone-receptor complex and G11alpha are both internalised into clathrin-coated vesicles.". Cell. Signal. 10 (8): 553–9. doi:10.1016/S0898-6568(97)00190-3. PMID 9794253.  
  • Matre V, Høvring PI, Orstavik S, et al. (1999). "Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor.". J. Neurochem. 72 (1): 40–50. doi:10.1046/j.1471-4159.1999.0720040.x. PMID 9886052.  
  • Kroeger KM, Hanyaloglu AC, Seeber RM, et al. (2001). "Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer.". J. Biol. Chem. 276 (16): 12736–43. doi:10.1074/jbc.M011311200. PMID 11278883.  
  • Zhu CC, Cook LB, Hinkle PM (2002). "Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation.". J. Biol. Chem. 277 (31): 28228–37. doi:10.1074/jbc.M204221200. PMID 12023974.  
  • Hanyaloglu AC, Seeber RM, Kohout TA, et al. (2003). "Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2.". J. Biol. Chem. 277 (52): 50422–30. doi:10.1074/jbc.M209340200. PMID 12393857.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Cook LB, Zhu CC, Hinkle PM (2004). "Thyrotropin-releasing hormone receptor processing: role of ubiquitination and proteasomal degradation.". Mol. Endocrinol. 17 (9): 1777–91. doi:10.1210/me.2003-0073. PMID 12805411.  
  • Igarashi-Migitaka J, Yamada S, Hara M, et al. (2004). "Gene expression study of thyrotropin releasing hormone (TRH) receptor using RT-PCR: relationship to clinical and immunohistochemical phenotypes in a series of human pituitary adenomas.". Endocr. J. 50 (4): 459–67. doi:10.1507/endocrj.50.459. PMID 14599121.  
  • Cook LB, Hinkle PM (2004). "Fate of internalized thyrotropin-releasing hormone receptors monitored with a timer fusion protein.". Endocrinology 145 (7): 3095–100. doi:10.1210/en.2004-0304. PMID 15117874.  

External links



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