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Tiletamine
Systematic (IUPAC) name
2-ethylamino-2-(2-thienyl) cyclohexanone
Identifiers
CAS number  ?
ATC code none
PubChem 26533
Chemical data
Formula C 12H17NOS 
Mol. mass 223.34 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism Liver
Half life  ?
Excretion Kidneys
Therapeutic considerations
Pregnancy cat.  ?
Legal status Schedule III (US)
Routes IV, IM, SC, Other

Tiletamine is a dissociative anesthetic and pharmacologically classified as an NMDA receptor antagonist. It is related chemically and pharmacologically to other anesthetics in this family such as ketamine and phencyclidine. Tiletamine hydrochloride exists as odourless white crystals.

It is used in veterinary medicine in the compound product Telazol (tiletamine/zolazepam, 50 mg/ml of each in 5 ml vial) as an injectable anesthetic. It is sometimes used in combination with xylazine (Rompun) to tranquilize large mammals such as bears and horses. Telazol is the only commercially available tiletamine product in the United States.

It is contraindicated in patients of an ASA score of III or greater and in animals with CNS signs, hyperthyroidism, cardiac disease, pancreatic or renal disease, pregnancy, glaucoma, or penetrating eye injuries.

Tiletamine products are classified as Schedule III controlled substances in the United States.

See also

References








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