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Tinidazole: Wikis


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Systematic (IUPAC) name
CAS number 19387-91-8
ATC code J01XD02 P01AB02 QP51AA02
PubChem 5479
DrugBank APRD01260
Chemical data
Formula C8H13N3O4S 
Mol. mass 247.273 g/mol
Pharmacokinetic data
Half life approx. 12.7 h
Therapeutic considerations
Pregnancy cat. C
Legal status
Routes oral
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Tinidazole is an anti-parasitic drug used against protozoan infections. It is widely known throughout Europe and the developing world as treatment for a variety of amoebic and parasitic infections.

Tinidazole is marketed by Mission Pharmacal under the brand name Tindamax, and by Pfizer under the name Fasigyn.



It is chemically similar to metronidazole—a drug with some unpleasant side effects that is used in the United States as first-line therapy for amoebae. Tinidazole has similar side effects but has a shorter treatment course with a more convenient dosage schedule.


Tinidazole is FDA approved for the treatment of trichomoniasis,. A large body of clinical data exists to support its use as a treatment for amoebae, giardia and vaginal trichomona, just like metronidazole. Tinidazole may be a therapeutic alternative in the setting of metronidazole tolerance.

Tinidazole may also be used to treat or prevent a variety of bacterial infections, including Helicobacter pylori.

A recent Phase II Randomized, Placebo-Controlled Double-Blind 4-Arm Trial for the Treatment of Non-Gonococcal Urethritis (NGU): Doxycycline (Plus or Minus Tinidazole) Versus Azithromycin (Plus or Minus Tinidazole).

Purpose of the study: to look at the safety, effectiveness, and tolerability of combination medications for the initial treatment of non-gonococcal urethritis (NGU). NGU is inflammation of the tube that carries urine from the bladder. NGU is caused by bacteria that may be passed from person to person during sex. This study will compare the 2 currently recommended NGU treatments, doxycycline and azithromycin, taken with tinidazole.

Side effects

The most common side effects reported with tinidazole are upset stomach, bitter taste, and itchiness. Other side effects which occur are headache, physical fatigue, and dizziness. Anecdotally, people who have taken both metronidazole and tinidazole report toxicity is much the same except the side effects don't last as long with the latter.

Drinking alcohol while taking tinidazole causes an unpleasant disulfiram-like reaction, which includes nausea, vomiting, headache, increased blood pressure, flushing and shortness of breath.

Half life

Elimination half-life is 13.2 ± 1.4 hours. Plasma half-life is 12 to 14 hours.


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