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Tobramycin: Wikis


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Systematic (IUPAC) name
(2S,3R,4S,5S,6 R)-4-amino-2-{[(1S,2S,3R,4S,6 R)-4,6-diamino-3-{[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-6-(hydroxymethyl)oxane-3,5-diol
CAS number 32986-56-4
ATC code J01GB01 S01AA12
PubChem 5496
DrugBank APRD00582
ChemSpider 33377
Chemical data
Formula C 18H37N5O9  
Mol. mass 467.515 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding < 30%
Metabolism  ?
Half life Neonates < 1200 g: 11 hrs; > 1200 g 2-9 hrs

Adults: 2-3 hours; longer with impaired renal function

Excretion  ?
Therapeutic considerations
Pregnancy cat. D (Injection, Inhalation); B (Ophthalmic) (US)
Legal status
Routes IV, IM, inhalation, ophthalmic

Tobramycin sulfate is an aminoglycoside antibiotic used to treat various types of bacterial infections, particularly Gram-negative infections.


Mechanism of action

Tobramycin works by binding to a site on the bacterial 30S and 50S ribosome, preventing formation of the 70S complex. As a result, mRNA cannot be translated into protein and cell death ensues. Tobramycin is preferred over gentamicin for Pseudomonas aeruginosa pneumonia due to better lung penetration and bactericidal activity.


Like all aminoglycosides, tobramycin does not pass the gastro-intestinal tract, so for systemic use it can only be given intravenously or intramuscularly. This formulation for injection is branded Nebcin. Patients with cystic fibrosis will often take an inhalational(nebulised) form (Tobi) for suppression of Pseudomonas aeruginosa infections. Tobramycin is also combined with dexamethasone as an ophthalmic solution (TobraDex).

Bausch & Lomb Pharmaceuticals, Inc. makes a sterile Tobramycin Ophtha Solution (eye-drops) with a tobramycin concentration of 0.3%, which is available by prescription only in the United States and Canada. (In some countries, such as Italy, it is available over the counter.) It is mixed with 0.01% benzalkonium chloride as a preservative. These concentrations result in 3 mg per ml and 0.1 mg per ml, respectively.

A proprietary formulation of micronized, nebulized tobramycin has been tested as a treatment for bacterial sinusitis.[1]

Side effects

Like other aminoglycosides, tobramycin can cause deafness or a loss of equilibrioception (vertigo) in genetically susceptible individual. These individuals have a normally harmless mutation in their DNA, that allows the tobramycin to affect their cells. The cells of the ear are particularly sensitive to this.

Tobramycin can also be highly toxic to the kidneys, particularly if multiple doses accumulate over a course of treatment.

For these reasons, when tobramycin is given parenterally, it is usually dosed by body weight. Various formulae exist for calculating tobramycin dosage. Also serum levels of tobramycin are monitored during treatment.


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