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Tolfenamic acid: Wikis

  

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Tolfenamic acid
Systematic (IUPAC) name
2-[(3-chloro-2-methylphenyl)amino]benzoic acid)[1]
Identifiers
CAS number 13710-19-5
ATC code M01AG02
PubChem 610479
Chemical data
Formula C 14H12ClNO2  
Mol. mass 261.707 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes oral

Tolfenamic acid (TA) is one of the class of non-steroidal anti-inflammatory drugs (NSAIDs). It is used to treat the symptoms of migraine.

Contents

Other possible uses

A study concludes, "TA was found significantly better than placebo in the subjective evaluation of drug efficacy (p<0.001) and in reducing the reported hangover symptoms in general (p < 0.01). In the TA group, significantly lower symptom scores were obtained for headache (p<0.01), and for nausea, vomiting, irritation, tremor, thirst and dryness of mouth (all p < 0.05)."[1]

Commercial names

Commercial names for tolfenamic acid include Clotam Rapid and Tufnil.

References

  1. ^ a b Kim Vilbour Andersen, Sine Larsen, Børge Alhede, Niels Gelting and Ole Buchardt (1989). "Characterization of two polymorphic forms of tolfenamic acid, N-(2-methyl-3-chlorophenyl)anthranilic acid: their crystal structures and relative stabilities". J. Chem. Soc., Perkin Trans. 2: 1443–1447. doi:10.1039/P29890001443. http://www.rsc.org/Publishing/Journals/P2/article.asp?doi=P29890001443.  

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