The Full Wiki

Tolperisone: Wikis

Advertisements
  

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Tolperisone
Systematic (IUPAC) name
2-methyl-1-(4-methylphenyl)-3-(1-piperidyl)propan-1-one
Identifiers
CAS number 728-88-1
ATC code M03BX04
PubChem 5511
Chemical data
Formula C 16H23NO 
Mol. mass 245.36 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Tolperisone, a piperidine derivative, is a centrally acting muscle relaxant. Brand names include Mydocalm and Mydeton.

A blister package of Mydocalm 50mg tablets intended for distribution in the Slovak Republic

Contents

Clinical use

Typically, Tolperisone is indicated in the treatment of acute muscle spasms in back pain and spasticity in neurological diseases.

Manufacturer claims

Tolperisone is currently marketed in Europe as a centrally-acting muscle relaxant which reportedly has special advantages over other drugs of its class in that it is reported not to cause drowsiness or lethargy according to some manufacturers. [1]

Besides claiming that "Tolperisone has an excellent efficacy & safety profile" these manufacturers also state[2] that Tolperisone has the unique property of mediating muscle relaxation without concomitant sedation nor does it cause impairment of coordination, weakness, mental confusion or withdrawal phenomena in contrast to other muscle relaxants.

Indications

Tolperisone is reportedly used in the typical treatment of the following conditions:

Contraindications and cautions

Manufacturers report that Tolperisone should not be used in the following conditions:

  • Myasthenia
  • Children under 1 years of age
  • Pregnancy
  • Breastfeeding

Side effects and adverse reactions

Some people using Tolperisone have reported [3] the following reactions:

The side effects and reactions listed above may not include all effects reported by the drug's manufacturer.

Interactions

It is believed that Tolperisone has few interactions with other medicines. However, this doesn't rule out any interactions that may or may not have been reported to care-givers thus far.

Some manufacturers have stated that Tolperisone may enhance the effects of other neuromuscular blocking agents.

Dosage

According to various sources, the typical oral adult dose for Tolperisone is 150mg to 450mg in a 24-hour period divided into two or three doses. It is highly advised that dosage information be confirmed by information provided from the manufacturer and prescriber.

More detailed dosage information [4] is as follows:

Adults over 12 years old:

  • Oral:50mg to 150mg every 8 hours
  • IM: 100mg every 12 hours.
  • IV: 100mg over 24 hours.

Pediatric Dosage (minimum weight of 20 Kg. minimum age 6 years old):

  • Oral dosage: 1.000 mg/kg every 8 hours.

Neonatal Dosage (minimum weight of 3 Kg.)

  • 2.500 mg/kg every 8 hours.

Also see

External links

  • Hofer D, Lohberger B, Steinecker B, Schmidt K, Quasthoff S, Schreibmayer W (2006). "A comparative study of the action of tolperisone on seven different voltage dependent sodium channel isoforms.". Eur J Pharmacol 538 (1-3): 5–14. doi:10.1016/j.ejphar.2006.03.034. PMID 16650844.  
  • Kocsis P, Farkas S, Fodor L, Bielik N, Thán M, Kolok S, Gere A, Csejtei M, Tarnawa I (2005). "Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels.". J Pharmacol Exp Ther 315 (3): 1237–46. doi:10.1124/jpet.105.089805. PMID 16126840.  
  • Ribi C, Vermeulen C, Hauser C (2003). "Anaphylactic reactions to tolperisone (Mydocalm).". Swiss Med Wkly 133 (25-26): 369–71. PMID 12947534.  

Footnotes

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message