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Toralizumab: Wikis

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From Wikipedia, the free encyclopedia

Toralizumab ?
Monoclonal antibody
Source Humanized
Target CD40 ligand
Identifiers
CAS number 252662-47-8
ATC code none
PubChem  ?
Chemical data
Formula  ?
Mol. mass 148,426 Daltons
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Toralizumab (IDEC 131) was a humanized monoclonal antibody and an immunosuppressive drug. Possible indications included treatment of antibody-mediated disorders (immune thrombocytopenic purpura, lupus nephritis, rheumatoid arthritis), T-cell-mediated diseases (multiple sclerosis, Crohn's disease, and transplantations such as solid organ transplantation, pancreatic islet cell transplantation, and corneal transplantation), and B-cell malignancies such as CLL/small lymphocytic lymphoma, follicular cell lymphoma grade I or II, marginal zone lymphoma, mantle cell lymphoma, MALT lymphoma, Waldenstrom's macroglobulinemia, monocytoid B-cell lymphoma; relapsed/refractory Hodgkin's disease).[1]

In Phase II clinical trials regarding multiple sclerosis and Crohn's disease, thromboembolisms occurred in at least three patients. A causal connection could not be proven, but since the same adverse effects were seen in trials with a similar antibody (hu5C8), the trials were halted.[2]

The drug was developed by IDEC Pharmaceuticals Corporation.

References

  1. ^ Statement On A Nonproprietary Name Adopted By The USAN Council - Toralizumab, American Medical Association.
  2. ^ Luebke, Robert W; Robert V House, Ian Kimber (2007). Immunotoxicology and immunopharmacology. Target Organ Toxicology Series (3 ed.). Boca Raton, Florida: CRC Press, Taylor & Francis Group. p. 131. ISBN 0-8493-3790-9. http://books.google.at/books?id=L7G38ea2wnAC&pg=PA131&lpg=PA131&dq=Toralizumab&source=bl&ots=I1JzPC9JrI&sig=BtBvqUADmWpI0SS1wmlW2h7Dajg&hl=de&ei=mUPwSsy_I4jt-Abo3rzqBw&sa=X&oi=book_result&ct=result&resnum=10&ved=0CC8Q6AEwCQ#v=onepage&q=Toralizumab&f=false.  
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