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Toscana virus: Wikis


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Toscana virus
Virus classification
Group: Group V ((-)ssRNA)
Family: Bunyaviridae
Genus: Phlebovirus
Species: Toscana virus

Toscana virus (TOSV) is an arthropod-borne virus arbovirus that was first isolated from the sandfly, Phlebotomus perniciosus collected from the Grosseto province of the Tuscany region in Italy[1], although has subsequently been identified isolated from P. perfiliewi, and found across a wider Mediterranean area. The virus can be transmitted to humans by the bite of an infected sandfly. Toscana is not normally associated with disease, as indicated by high seroprevalence rates (up to 25%) in areas where Toscana virus is present, but in common with other sandfly transmitted viruses such as Naples virus and Sicilian virus may result in a mild illness with fever, headache, myalgiapappataci fever — that may go undiagnosed, in more serious cases Toscana virus can cause an acute meningitis, and meningoencephalitis.


Molecular Virology


Virions consist of an envelope and a nucleocapsid.


The genome consists of three negative sense RNA segments, termed L (~6400 bases), M (~4200 bases) and S (~1900 bases) which encode the viral polymerase, structural glycoproteins proteins and nucleo proteins respectively.




Genetic analysis


  1. ^ Verani, P., Nicoletti L., Ciufolini, M.G., (1984) Antigenic and biological characterization of Toscana virus, a new Phlebotomus fever group virus isolated in italy. Acta Virol. 28:39-47

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