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Toxic nodular goitre
Classification and external resources
ICD-10 E05.1-E05.2
DiseasesDB 13184
MedlinePlus 000317

Toxic nodular goiter (or Plummer syndrome) is a condition that can occur when a hyper-functioning nodule develops within a longstanding goiter. The result is hyperthyroidism, without the ophthalmologic effects of increased levels of thyroid hormone as in Grave's disease. These toxic multi or uni-nodular goiters are most common in women over the age of 60.[1]

It was named by Henry Stanley Plummer.[2][3]


  1. ^ Stedman's Electronic Medical Dictionary
  2. ^ synd/1094 at Who Named It?
  3. ^ H. S. Plummer. The clinical and pathological relationship of simple and exophthalmic goiter. American Journal of the Medical Sciences, Thorofare, N.J., 1913, 146: 790-795. Transactions of the Association of American Physicians, Philadelphia, 1928, 43: 159.


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