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Transcortin: Wikis

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Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6, also Corticosteroid-Binding Globulin or Transcortin
Transcortin.png
Structure of corticosteroid-binding globulin in complex with cortisol.
Identifiers
Symbol SERPINA6
Alt. symbols CBG
Entrez 866
HUGO 1540
OMIM 122500
RefSeq NM_001750
UniProt P08185
Other data
Locus Chr. 14 q32.1

Transcortin, also corticosteroid-binding globulin or CBG, is officially called serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6.

It is an alpha-globulin.

Binding

Transcortin binds several steroid hormones:

  • Cortisol. Approximately 75% of the cortisol in circulation is bound to this plasma protein. (The rest is bound to serum albumin.) The cortisol is thought to be biologically active only when it is not bound to transcortin.
  • Aldosterone. 60% of the aldosterone in blood is bound to this plasma protein.

Production

Transcortin is produced by the liver and is regulated by estrogens. Therefore, plasma transcortin levels increase during pregnancy, and are decreased in cirrhosis.

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