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General transcription factor IIB

PDB rendering based on 1c9b.
Available structures
1c9b, 1dl6, 1rly, 1ro4, 1tfb, 1vol, 2phg
Symbols GTF2B; TF2B; TFIIB
External IDs OMIM189963 MGI2385191 HomoloGene1158 GeneCards: GTF2B Gene
RNA expression pattern
PBB GE GTF2B 208066 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2959 229906
Ensembl ENSG00000137947 ENSMUSG00000028271
UniProt Q00403 Q3ULN2
RefSeq (mRNA) NM_001514 NM_145546
RefSeq (protein) NP_001505 NP_663521
Location (UCSC) Chr 1:
89.09 - 89.13 Mb
Chr 3:
142.7 - 142.72 Mb
PubMed search [1] [2]

Transcription factor II B (TFIIB) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.[1] It is encoded by the TFIIB gene.[2][3]

Transcription factor IIB localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. The protein serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II.[4] It is involved in the selection of the transcription start site: mutations in TFIIB cause a shift in the transcription start site.[5]



Transcription Factor II B has been shown to interact with CREB binding protein,[6][7] GTF2H4,[8] TATA binding protein,[8][9] POLR2A,[8] TAF11,[8] GTF2F1[8][10] and C-jun.[11]

See also


  1. ^ Lewin, Benjamin (2004). Genes VIII. Upper Saddle River, NJ: Pearson Prentice Hall. pp. p636–637. ISBN 0-13-144946-X.  
  2. ^ Ha I, Lane WS, Reinberg D (1991). "Cloning of a human gene encoding the general transcription initiation factor IIB". Nature 352 (6337): 689–95. doi:10.1038/352689a0. PMID 1876184.  
  3. ^ Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet. 3 (1): 61–4. doi:10.1093/hmg/3.1.61. PMID 8162052.  
  4. ^ "Entrez Gene: GTF2B general transcription factor IIB".  
  5. ^ Lee TI, Young RA (2000). "Transcription of eukaryotic protein-coding genes". Annu. Rev. Genet. 34: 77–137. doi:10.1146/annurev.genet.34.1.77. PMID 11092823.  
  6. ^ Tini, Marc; Benecke Arndt, Um Soo-Joong, Torchia Joseph, Evans Ronald M, Chambon Pierre (Feb. 2002). "Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription". Mol. Cell (United States) 9 (2): 265–77. ISSN 1097-2765. PMID 11864601.  
  7. ^ Fan, Saijun; Ma Yong Xian, Wang Chenguang, Yuan Ren-Qi, Meng Qinghui, Wang Ji-An, Erdos Michael, Goldberg Itzhak D, Webb Paul, Kushner Peter J, Pestell Richard G, Rosen Eliot M (Jan. 2002). "p300 Modulates the BRCA1 inhibition of estrogen receptor activity". Cancer Res. (United States) 62 (1): 141–51. ISSN 0008-5472. PMID 11782371.  
  8. ^ a b c d e Scully, R; Anderson S F, Chao D M, Wei W, Ye L, Young R A, Livingston D M, Parvin J D (May. 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (11): 5605–10. ISSN 0027-8424. PMID 9159119.  
  9. ^ Bushnell, David A; Westover Kenneth D, Davis Ralph E, Kornberg Roger D (Feb. 2004). "Structural basis of transcription: an RNA polymerase II-TFIIB cocrystal at 4.5 Angstroms". Science (United States) 303 (5660): 983–8. doi:10.1126/science.1090838. PMID 14963322.  
  10. ^ Fang, S M; Burton Z F (May. 1996). "RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding". J. Biol. Chem. (UNITED STATES) 271 (20): 11703–9. ISSN 0021-9258. PMID 8662660.  
  11. ^ Franklin, C C; McCulloch A V, Kraft A S (Feb. 1995). "In vitro association between the Jun protein family and the general transcription factors, TBP and TFIIB". Biochem. J. (ENGLAND) 305 ( Pt 3): 967–74. ISSN 0264-6021. PMID 7848298.  

Further reading

  • Roeder RG (1996). "The role of general initiation factors in transcription by RNA polymerase II.". Trends Biochem. Sci. 21 (9): 327–35. PMID 8870495.  
  • Kino T, Pavlakis GN (2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1.". DNA Cell Biol. 23 (4): 193–205. doi:10.1089/104454904773819789. PMID 15142377.  
  • Kino T, Chrousos GP (2004). "Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?". Ann. N. Y. Acad. Sci. 1024: 153–67. doi:10.1196/annals.1321.013. PMID 15265780.  
  • Seelamgari A, Maddukuri A, Berro R, et al. (2006). "Role of viral regulatory and accessory proteins in HIV-1 replication.". Front. Biosci. 9: 2388–413. doi:10.2741/1403. PMID 15353294.  
  • Ing NH, Beekman JM, Tsai SY, et al. (1992). "Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II).". J. Biol. Chem. 267 (25): 17617–23. PMID 1517211.  
  • Malik S, Hisatake K, Sumimoto H, et al. (1991). "Sequence of general transcription factor TFIIB and relationships to other initiation factors.". Proc. Natl. Acad. Sci. U.S.A. 88 (21): 9553–7. doi:10.1073/pnas.88.21.9553. PMID 1946368.  
  • Klemm RD, Goodrich JA, Zhou S, Tjian R (1995). "Molecular cloning and expression of the 32-kDa subunit of human TFIID reveals interactions with VP16 and TFIIB that mediate transcriptional activation.". Proc. Natl. Acad. Sci. U.S.A. 92 (13): 5788–92. doi:10.1073/pnas.92.13.5788. PMID 7597030.  
  • Veschambre P, Simard P, Jalinot P (1995). "Evidence for functional interaction between the HIV-1 Tat transactivator and the TATA box binding protein in vivo.". J. Mol. Biol. 250 (2): 169–80. doi:10.1006/jmbi.1995.0368. PMID 7608968.  
  • Desai-Yajnik V, Hadzic E, Modlinger P, et al. (1995). "Interactions of thyroid hormone receptor with the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and the HIV-1 Tat transactivator.". J. Virol. 69 (8): 5103–12. PMID 7609079.  
  • Cavaillès V, Dauvois S, L'Horset F, et al. (1995). "Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.". EMBO J. 14 (15): 3741–51. PMID 7641693.  
  • Nakshatri H, Nakshatri P, Currie RA (1995). "Interaction of Oct-1 with TFIIB. Implications for a novel response elicited through the proximal octamer site of the lipoprotein lipase promoter.". J. Biol. Chem. 270 (33): 19613–23. PMID 7642649.  
  • Abendroth FD, Peterson SR, Galman M, et al. (1995). "Identification of human autoantibodies to transcription factor IIB.". Nucleic Acids Res. 23 (14): 2770–4. doi:10.1093/nar/23.14.2770. PMID 7651839.  
  • Bagby S, Kim S, Maldonado E, et al. (1995). "Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein.". Cell 82 (5): 857–67. doi:10.1016/0092-8674(95)90483-2. PMID 7671313.  
  • Nikolov DB, Chen H, Halay ED, et al. (1995). "Crystal structure of a TFIIB-TBP-TATA-element ternary complex.". Nature 377 (6545): 119–28. doi:10.1038/377119a0. PMID 7675079.  
  • Schmitz ML, Stelzer G, Altmann H, et al. (1995). "Interaction of the COOH-terminal transactivation domain of p65 NF-kappa B with TATA-binding protein, transcription factor IIB, and coactivators.". J. Biol. Chem. 270 (13): 7219–26. doi:10.1074/jbc.270.13.7219. PMID 7706261.  
  • Yu L, Zhang Z, Loewenstein PM, et al. (1995). "Molecular cloning and characterization of a cellular protein that interacts with the human immunodeficiency virus type 1 Tat transactivator and encodes a strong transcriptional activation domain.". J. Virol. 69 (5): 3007–16. PMID 7707527.  
  • Yu L, Loewenstein PM, Zhang Z, Green M (1995). "In vitro interaction of the human immunodeficiency virus type 1 Tat transactivator and the general transcription factor TFIIB with the cellular protein TAP.". J. Virol. 69 (5): 3017–23. PMID 7707528.  
  • Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". C. R. Acad. Sci. III, Sci. Vie 318 (2): 263–72. PMID 7757816.  
  • Franklin CC, McCulloch AV, Kraft AS (1995). "In vitro association between the Jun protein family and the general transcription factors, TBP and TFIIB.". Biochem. J. 305 ( Pt 3): 967–74. PMID 7848298.  

External links



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