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general transcription factor IIF, polypeptide 1, 74kDa
Identifiers
Symbol GTF2F1
Alt. symbols TFIIF, BTF4, RAP74
Entrez 2962
HUGO 4652
OMIM 189968
RefSeq NM_002096
UniProt P35269
Other data
Locus Chr. 19 p13.3
general transcription factor IIF, polypeptide 2, 30kDa
Identifiers
Symbol GTF2F2
Alt. symbols TFIIF, BTF4, RAP30
Entrez 2963
HUGO 4653
OMIM 189969
RefSeq NM_004128
UniProt P13984
Other data
Locus Chr. 13 q14
general transcription factor IIF, polypeptide 2-like
Identifiers
Symbol GTF2F2L
Alt. symbols TFIIF
Entrez 2964
HUGO 4654
RefSeq NG_003013
Other data
Locus Chr. 4 q31.22

Transcription factor II F (TFIIF) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.[1]

Transcription Factor II F is encoded by the GTF2F1, GTF2F2, and GTF2F2L genes.[2][3][4] DNA is thought to be wrapped one complete turn around the preinitiation complex and it is TFIIF that helps keep this tight wrapping.[5] In the process, the torsional strain on the DNA may aid in DNA melting at the promoter, forming the transcription bubble. Of all the general transcription factors, TFIIF is the most similar to bacterial sigma factor.[5]

See also

References

  1. ^ Lewin, Benjamin (2004). Genes VIII. Upper Saddle River, NJ: Pearson Prentice Hall. pp. p636–637. ISBN 0-13-144946-X.  
  2. ^ Finkelstein A, Kostrub CF, Li J, Chavez DP, Wang BQ, Fang SM, Greenblatt J, Burton ZF (1992). "A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II". Nature 355 (6359): 464–7. doi:10.1038/355464a0. PMID 1734284.  
  3. ^ Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet. 3 (1): 61–4. doi:10.1093/hmg/3.1.61. PMID 8162052.  
  4. ^ Purrello M, Di Pietro C, Rapisarda A, Mirabile E, Motta S, Sichel G, Grzeschik KH (1995). "Genetic characterization of general transcription factors TFIIF and TFIIB of Homo sapiens sapiens". Cytogenet. Cell Genet. 69 (1-2): 75–80. doi:10.1159/000133942. PMID 7835093.  
  5. ^ a b Lee TI, Young RA (2000). "Transcription of eukaryotic protein-coding genes". Annu. Rev. Genet. 34: 77–137. doi:10.1146/annurev.genet.34.1.77. PMID 11092823.  

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