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Transporter Classification database (or TCDB) is an International Union of Biochemistry and Molecular Biology (IUBMB) approved classification system for membrane transport proteins including ion channels. This classification system was designed to be analogous to the EC number system for classifying enzymes, but it also uses phylogenetic information.

The upper level of classification and a few examples of proteins with known 3D structure:

1. Channels/Pores

2. Electrochemical Potential-driven transporters

    • Mitochondrial carrier proteins [9]
    • Major Facilitator Superfamily (Glycerol-3-hosphate transporter, Lactose permease, and Multidrug transporter EmrD) [10]
    • Resistance-nodulation-cell division (multidrug efflux transporter AcrB, see multidrug resistance)[11]
    • Dicarboxylate/amino acid:cation symporter (proton glutamate symporter) [12]
    • Monovalent cation/proton antiporter (Sodium/proton antiporter 1 NhaA) [13]
    • Neurotransmitter sodium symporter [14]
    • Ammonia transporters [15]
    • Drug/Metabolite Transporter (small multidrug resistance transporter EmrE - the structures are retracted as erroneous) [16]

3. Primary Active Transporters

4. Group Translocators

5. Transport Electron Carriers

    • Disulfide bond formation protein B (DsbB) [26]

8. Accessory Factors Involved in Transport

9. Incompletely Characterized Transport Systems


See also

External links

  • Busch W, Saier MH (2002). "The transporter classification (TC) system, 2002". Crit. Rev. Biochem. Mol. Biol. 37 (5): 287–337. PMID 12449427.  


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