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Triamcinolone
Systematic (IUPAC) name
(11β,16α)-9-fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
Identifiers
CAS number 124-94-7
ATC code A01AC01 D07AB09, D07XB02, H02AB08, R01AD11, R03BA06, S01BA05
PubChem 31307
DrugBank APRD00422
ChemSpider 29046
Chemical data
Formula C 21H27FO6  
Mol. mass 394.434 g/mol
SMILES eMolecules & PubChem
Synonyms (8S,9R,10S,11S,13S,14 S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3 H-cyclopenta[a]phenanthren-3-one; (1R,2S,10S,11S,13R,14 S,15S,17S)-1-fluoro-13,14,17-trihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0 2,7.011,15]heptadeca-3,6-dien-5-one
Pharmacokinetic data
Bioavailability  ?
Protein binding 68%
Metabolism Hepatic
Half life 88 minutes
Excretion Fecal and renal
Therapeutic considerations
Pregnancy cat. A(AU) C(US)
Legal status POM (UK) -only (US)
Routes Oral, topical, IM, intra-articular, intrasynovial
 Yes check.svgY(what is this?)  (verify)

Triamcinolone (trade names Kenalog, Aristocort, Nasacort, Tri-Nasal, Triderm, Azmacort, Trilone, Volon A, Tristoject, Fougera, Tricortone,Triesence;) is a synthetic corticosteroid given orally, by injection, inhalation, or as a topical ointment or cream.

Contents

Uses

Triamcinolone is used to treat several different medical conditions, such as eczema, psoriasis, arthritis, allergies, ulcerative colitis, lupus, sympathetic ophthalmia, temporal arteritis, uveitis, and ocular inflammation, visualization during vitrectomy and the prevention of asthma attacks. It will not treat an asthma attack once it has already begun.[1][2][3]

Forms

Different triamcinolone salts are available, including acetonide, benetonide, furetonide, hexacetonide and diacetate.

Triamcinolone acetonide is a more potent type of triamcinolone, being about eight times as effective as prednisone.

Side effects

Side effects of Triamcinolone include sore throat, nosebleeds, increased coughing, headache, and runny nose. White patches in the throat or nose indicates a serious side effect. Symptoms of an allergic reaction include rash, itch, swelling, severe dizziness, trouble breathing.[4]

An additional side effect for women is a prolonged menstrual cycle.

References

  1. ^ Triamcinolone - Drugs.com
  2. ^ Triamcinolone inhalation - Drugs.com
  3. ^ Alcon Receives FDA Approval of Triesence Injectable Triamcinolone Suspension for Use in Eye Surgery
  4. ^ "Drugs and Treatments - Nasacort AQ Nasl - Patient Handout". WebMD. http://www.webmd.com/drugs/drug-16244-Nasacort+AQ.aspx?drugid=16244&drugname=Nasacort%20AQ. Retrieved 2008-03-24.  
Aristocort topical cream (AU)
Kenalog injection (SCO)

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