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Tribendimidine
Systematic (IUPAC) name
N,N'-bis(4-(1-dimethylamino)ethylideneaminophenyl)-1,4
-phenylene dimethylidyneamine
Identifiers
CAS number 115103-15-6
ATC code none
PubChem 3086564
Chemical data
Formula C 28H32N6  
Mol. mass 452.594 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Tribendimidine is a broad-spectrum anthelmintic agent developed in China, at the National Institute of Parasitic Diseases in Shanghai. It is a derivative of amidantel.[1]

In clinical trials, it was highly effective in treating ankylostomiasis, ascariasis and enterobiasis.[2] However, animal studies suggest it is ineffective in treating Schistosoma mansoni or Fasciola hepatica disease.[1]

Tribendimidine is associated with Shandong Xinhua Pharmaceutical Company Limited in Zibo, Shandong, China.

References

  1. ^ a b Keiser J, Shu-Hua X, Chollet J, Tanner M, Utzinger J (2007). "Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini". Antimicrob Agents Chemother 51 (3): 1096–8. doi:10.1128/AAC.01366-06. PMID 17194822.   Free full text
  2. ^ Xiao SH, Hui-Ming W, Tanner M, Utzinger J, Chong W (2005). "Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China". Acta Trop 94 (1): 1–14. doi:10.1016/j.actatropica.2005.01.013. PMID 15777691.  
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