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Metrifonate
Systematic (IUPAC) name
(RS)-2,2,2-trichloro-1-dimethoxyphosphoryl-ethanol
Identifiers
CAS number 52-68-6
ATC code P02BB01 QP52AB01 QP53AF02
PubChem 5853
Chemical data
Formula C 4H8Cl3O4P 
Mol. mass 257.436 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?
 Yes check.svgY(what is this?)  (verify)

Metrifonate (INN) or trichlorfon (USAN) is an organophosphate acetylcholinesterase inhibitor.

It is classified as irreversible. [1]

It can be used to treat schistosomiasis caused by Schistoma haematobium but is no longer commercially available.[2]

It has been proposed for use in treatment of Alzheimer's disease, but use for that purpose is not currently recommended.[3]

References

  1. ^ "NLH - Neurological Conditions - Metrifonate for Alzheimer's disease". http://www.library.nhs.uk/neurological/ViewResource.aspx?resID=237789.  
  2. ^ "Schistosomiasis". 2002. pp. 1212–1220. http://content.nejm.org/cgi/reprint/346/16/1212.  
  3. ^ López-Arrieta J, Schneider L (2008). "Metrifonate for Alzheimer's disease". Cochrane Database of Systematic Reviews (1): CD003155. doi:10.1002/14651858.CD003155.pub3.  
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