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Triclabendazole
Systematic (IUPAC) name
5-chloro-6-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole
Identifiers
CAS number 68786-66-3
ATC code P02BX04 QP52AC01
PubChem 50248
Chemical data
Formula C14H9Cl3N2OS 
Mol. mass 359.658
Pharmacokinetic data
Metabolism oxidation to the sulfone and sulfoxide parent compound
Half life 22 - 24 hs
Excretion >95% in faeces, 2% in urine, and < 1% in milk
Therapeutic considerations
Pregnancy cat.  ?
Legal status  ?
Routes  ?

Triclabendazole (commercial names: veterinary, liquid: Fasinex; human, tablets: Egaten; both manufactured by Novartis) is a member of the Benzimidazole family of anthelmintics. The benzimidazole drugs share a common molecular structure, triclabendazole being the exception in having a chlorinated benzene ring but no carbamate group.

Triclabendazole displays high efficacy against both immature and adult liver fluke.

It is generally accepted that benzimidazoles like triclabendazole bind to beta-tubulin and prevent the polymerisation of the microtubules of which they are part.








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