The Full Wiki

More info on Triclabendazole

Triclabendazole: Wikis

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

Systematic (IUPAC) name
CAS number 68786-66-3
ATC code P02BX04 QP52AC01
PubChem 50248
Chemical data
Formula C14H9Cl3N2OS 
Mol. mass 359.658
Pharmacokinetic data
Metabolism oxidation to the sulfone and sulfoxide parent compound
Half life 22 - 24 hs
Excretion >95% in faeces, 2% in urine, and < 1% in milk
Therapeutic considerations
Pregnancy cat.  ?
Legal status  ?
Routes  ?

Triclabendazole (commercial names: veterinary, liquid: Fasinex; human, tablets: Egaten; both manufactured by Novartis) is a member of the Benzimidazole family of anthelmintics. The benzimidazole drugs share a common molecular structure, triclabendazole being the exception in having a chlorinated benzene ring but no carbamate group.

Triclabendazole displays high efficacy against both immature and adult liver fluke.

It is generally accepted that benzimidazoles like triclabendazole bind to beta-tubulin and prevent the polymerisation of the microtubules of which they are part.

Got something to say? Make a comment.
Your name
Your email address