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Trimethadione: Wikis


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Systematic (IUPAC) name
CAS number 127-48-0
ATC code N03AC02
PubChem 5576
DrugBank APRD00315
Chemical data
Formula C 6H9NO3  
Mol. mass 143.141 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat. X
Legal status Prescription only
Routes  ?

Trimethadione is an oxazolidinedione anticonvulsant. It is used to treat epileptic conditions that are resistant to other treatments; recent studies by Doctor Jianxin Bao, Ph.D., at Washington University in Saint Louis's Central Institute For The Deaf's Center For Presbyacusis and Aging suggest that trimethadione, along with other oxazolidinedione anticonvulsant medications may be useful in treating sensorineural hearing loss cases like those of Iraq war veterans- if the drug's side effects, like dizziness, can be lessened by modifying the drug so it does not cross into the brain itself.

Fetal trimethadione syndrome

If administered during pregnancy, fetal trimethadione syndrome may result causing facial dysmorphism (short upturned nose, slanted eyebrows), cardiac defects, intrauterine growth retardation (IUGR), and mental retardation. The fetal loss rate while using trimethadione has been reported to be as high as 87%.[1]


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