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Tuaminoheptane
Systematic (IUPAC) name
heptan-2-amine
Identifiers
CAS number 123-82-0
ATC code R01AA11
PubChem 5603
Chemical data
Formula C 7H17N 
Mol. mass 115.217 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?


Tuaminoheptane (or tuamine) is a nasal decongestant drug which is a sympathomimetic stimulant and vasoconstrictor.[1] However it can cause skin irritation,[2] which limits its usefulness as a nasal decongestant. Side effects can include acute glaucoma, tachycardia and hypertension.[1]

Tuaminoheptane is contained in the 2008 list of prohibited substances published by the World Anti-Doping Agency.

References

  1. ^ Delicado EG, Fideu MD, Miras-Portugal MT, Pourrias B, Aunis D. Effect of tuamine, heptaminol and two analogues on uptake and release of catecholamines in cultured chromaffin cells. Biochemical Pharmacology. 1990 Aug 15;40(4):821-5.
  2. ^ Raoux M, Colomban C, Delmas P, Crest M. The amine-containing cutaneous irritant heptylamine inhibits the volume-regulated anion channel and mobilizes intracellular calcium in normal human epidermal keratinocytes. Molecular Pharmacology. 2007 Jun;71(6):1685-94.

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