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U-50488: Wikis


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Systematic (IUPAC) name
CAS number 67198-13-4
ATC code  ?
PubChem 3036289
Chemical data
Formula C 19H26Cl2N2O 
Mol. mass 369.329 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

U-50488 is a drug which acts as a highly selective κ-opioid agonist, but without any μ-opioid antagonist effects.[1] It has analgesic, diuretic and antitussive effects,[2] and reverses the memory impairment produced by anticholinergic drugs.[3] U-50488 was one of the first selective kappa agonists invented and research on its derivatives has led to the development of a large family of related compounds.[4][5]


  1. ^ Von Voigtlander PF, Lewis RA. U-50,488, a selective kappa opioid agonist: comparison to other reputed kappa agonists. Progress in Neuropsychopharmacology and Biological Psychiatry. 1982;6(4-6):467-70. PMID 6298890
  2. ^ Kamei J. Role of opioidergic and serotonergic mechanisms in cough and antitussives. Pulmonary Pharmacology. 1996 Oct-Dec;9(5-6):349-56. PMID 9232674
  3. ^ Hiramatsu M, Kameyama T. Roles of kappa-opioid receptor agonists in learning and memory impairment in animal models. Methods and Findings in Experimental and Clinical Pharmacology. 1998 Sep;20(7):595-9. PMID 9819804
  4. ^ Szmuszkovicz J. U-50,488 and the kappa receptor: a personalized account covering the period 1973 to 1990. Progress in Drug Research. 1999;52:167-95. PMID 10396128
  5. ^ Szmuszkovicz J. U-50,488 and the kappa receptor. Part II: 1991-1998. Progress in Drug Research. 1999;53:1-51. PMID 10616295


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