The Full Wiki

More info on U-50488

U-50488: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

U-50488
Systematic (IUPAC) name
2-(3,4-dichlorophenyl)-N-methyl-N-[(1R,2R)-2-pyrrolidin-1-ylcyclohexyl]acetamide
Identifiers
CAS number 67198-13-4
ATC code  ?
PubChem 3036289
Chemical data
Formula C 19H26Cl2N2O 
Mol. mass 369.329 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

U-50488 is a drug which acts as a highly selective κ-opioid agonist, but without any μ-opioid antagonist effects.[1] It has analgesic, diuretic and antitussive effects,[2] and reverses the memory impairment produced by anticholinergic drugs.[3] U-50488 was one of the first selective kappa agonists invented and research on its derivatives has led to the development of a large family of related compounds.[4][5]

References

  1. ^ Von Voigtlander PF, Lewis RA. U-50,488, a selective kappa opioid agonist: comparison to other reputed kappa agonists. Progress in Neuropsychopharmacology and Biological Psychiatry. 1982;6(4-6):467-70. PMID 6298890
  2. ^ Kamei J. Role of opioidergic and serotonergic mechanisms in cough and antitussives. Pulmonary Pharmacology. 1996 Oct-Dec;9(5-6):349-56. PMID 9232674
  3. ^ Hiramatsu M, Kameyama T. Roles of kappa-opioid receptor agonists in learning and memory impairment in animal models. Methods and Findings in Experimental and Clinical Pharmacology. 1998 Sep;20(7):595-9. PMID 9819804
  4. ^ Szmuszkovicz J. U-50,488 and the kappa receptor: a personalized account covering the period 1973 to 1990. Progress in Drug Research. 1999;52:167-95. PMID 10396128
  5. ^ Szmuszkovicz J. U-50,488 and the kappa receptor. Part II: 1991-1998. Progress in Drug Research. 1999;53:1-51. PMID 10616295
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message