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U-90042: Wikis

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U-90042
Systematic (IUPAC) name
11-Chloro-5-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-2,3-dihydrodiimidazo[1,2-c:1',5'-a]quinazoline
Identifiers
CAS number 134516-99-7
ATC code  ?
PubChem 9928470
Chemical data
Formula C17H13ClN6O 
Mol. mass 352.78 g/mol
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status

U-90042 is a sedative and hypnotic drug used in scientific research. It has similar effects to sedative-hypnotic benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine hypnotic.

U-90042 is a GABAA agonist acting primarily at the α1, α3 and α6 subtypes, with a Ki of 7.8nM at α1, 9.5nM at α3 and 11.0nM at α6. It produces sedation and ataxia and prolongs sleeping time in mice, rats and monkeys, but does not produce amnesia and blocks the amnestic effect of diazepam, reflecting its different subtype affinity compared to benzodiazepine drugs.[1]

References

  1. ^ Tang AH, Smith MW, Carter DB, Im WB, VonVoigtlander PF. U-90042, a sedative/hypnotic compound that interacts differentially with the GABAA receptor subtypes. Journal of Pharmacology and Experimental Therapeutics. 1995 Nov;275(2):761-7. PMID 7473164
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