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U-92,016-A
Systematic (IUPAC) name
(8R)-8-(Dipropylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-2-carbonitrile
Identifiers
CAS number 149654-41-1
ATC code  ?
PubChem  ?
Chemical data
Formula C 19H25N3  
Mol. mass 295.421 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

U-92,016-A is a psychoactive drug and research chemical used in scientific studies. It acts as a potent, high efficacy, and selective 5-HT1A receptor full agonist with a long duration of action.[1][2] It has been suggested that it could be developed as an anxiolytic or antidepressant drug.[1]

References

  1. ^ a b Romero AG, Leiby JA, McCall RB, Piercey MF, Smith MW, Han F. (1993). "Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants.". J Med Chem. 36 (15): 2066–2074. PMID 8101876.  
  2. ^ McCall RB, Romero AG, Bienkowski MJ, Harris DW, McGuire JC, Piercey MF, Shuck ME, Smith MW, Svensson KA, Schreur PJ, et al. (1994). "Characterization of U-92016A as a selective, orally active, high intrinsic activity 5-hydroxytryptamine1A agonist.". J Pharmacol Exp Ther. 271 (2): 875–883. PMID 7965808.  

U-92016A
Systematic (IUPAC) name
(8R)-8-(Dipropylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-2-carbonitrile
Identifiers
CAS number 149654-41-1
ATC code  ?
PubChem  ?
Chemical data
Formula C19H25N3 
Mol. mass 295.421 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes  ?

U-92016A is a drug and research chemical used in scientific studies. It acts as a potent, high efficacy, and selective 5-HT1A receptor full agonist with a long duration of action.[1][2] It has been suggested that it could be developed as an anxiolytic or antidepressant drug.[1]

References

  1. 1.0 1.1 Romero AG, Leiby JA, McCall RB, Piercey MF, Smith MW, Han F. (1993). "Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants.". J Med Chem. 36 (15): 2066-2074. PMID 8101876. 
  2. McCall RB, Romero AG, Bienkowski MJ, Harris DW, McGuire JC, Piercey MF, Shuck ME, Smith MW, Svensson KA, Schreur PJ, et al. (1994). "Characterization of U-92016A as a selective, orally active, high intrinsic activity 5-hydroxytryptamine1A agonist.". J Pharmacol Exp Ther. 271 (2): 875-883. PMID 7965808. 







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