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UGT2B10: Wikis


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From Wikipedia, the free encyclopedia

UDP glucuronosyltransferase 2 family, polypeptide B10

PDB rendering based on 2o6l.
Available structures
Symbols UGT2B10; MGC142209
External IDs OMIM600070 MGI2140962 HomoloGene68157 GeneCards: UGT2B10 Gene
RNA expression pattern
PBB GE UGT2B10 211682 x at tn.png
More reference expression data
Species Human Mouse
Entrez 7365 100727
Ensembl ENSG00000109181 ENSMUSG00000029260
UniProt P36537 n/a
RefSeq (mRNA) NM_001075 NM_153598
RefSeq (protein) NP_001066 NP_705826
Location (UCSC) Chr 4:
69.72 - 69.73 Mb
Chr 5:
87.96 - 87.98 Mb
PubMed search [1] [2]

UDP-glucuronosyltransferase 2B10 is an enzyme that in humans is encoded by the UGT2B10 gene.[1][2]


  1. ^ Jin CJ, Miners JO, Lillywhite KJ, Mackenzie PI (Aug 1993). "cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily". Biochem Biophys Res Commun 194 (1): 496-503. doi:10.1006/bbrc.1993.1847. PMID 8333863.  
  2. ^ "Entrez Gene: UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10".  

Further reading

  • Chen G, Dellinger RW, Gallagher CJ, et al. (2008). "Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines.". Pharmacogenet. Genomics 18 (3): 181–91. doi:10.1097/FPC.0b013e3282f4dbdd. PMID 18300939.  
  • Chen G, Blevins-Primeau AS, Dellinger RW, et al. (2007). "Glucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism.". Cancer Res. 67 (19): 9024–9. doi:10.1158/0008-5472.CAN-07-2245. PMID 17909004.  
  • Kaivosaari S, Toivonen P, Hesse LM, et al. (2007). "Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10.". Mol. Pharmacol. 72 (3): 761–8. doi:10.1124/mol.107.037093. PMID 17576790.  
  • Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Strassburg CP, Kneip S, Topp J, et al. (2000). "Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine.". J. Biol. Chem. 275 (46): 36164–71. doi:10.1074/jbc.M002180200. PMID 10748067.  
  • Strassburg CP, Strassburg A, Nguyen N, et al. (1999). "Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus.". Biochem. J. 338 ( Pt 2): 489–98. doi:10.1042/0264-6021:3380489. PMID 10024527.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  


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