The Full Wiki

More info on USF2

USF2: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

Upstream transcription factor 2, c-fos interacting
Symbols USF2; FIP
External IDs OMIM600390 MGI99961 HomoloGene2527 GeneCards: USF2 Gene
RNA expression pattern
PBB GE USF2 202152 x at tn.png
PBB GE USF2 214879 x at tn.png
PBB GE USF2 215737 x at tn.png
More reference expression data
Species Human Mouse
Entrez 7392 22282
Ensembl ENSG00000105698 n/a
UniProt Q15853 n/a
RefSeq (mRNA) NM_003367 XM_001001413
RefSeq (protein) NP_003358 XP_001001413
Location (UCSC) Chr 19:
40.45 - 40.46 Mb
PubMed search [1] [2]

Upstream stimulatory factor 2 is a protein that in humans is encoded by the USF2 gene.[1][2]

This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. Two transcript variants encoding distinct isoforms have been identified for this gene.[2]


USF2 has been shown to interact with USF1 (human gene),[3][4] PPRC1[5] and BRCA1.[6]


  1. ^ Groenen PM, Garcia E, Debeer P, Devriendt K, Fryns JP, Van de Ven WJ (Mar 1997). "Structure, sequence, and chromosome 19 localization of human USF2 and its rearrangement in a patient with multicystic renal dysplasia". Genomics 38 (2): 141–8. PMID 8954795.  
  2. ^ a b "Entrez Gene: USF2 upstream transcription factor 2, c-fos interacting".  
  3. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3: 89. doi:10.1038/msb4100134. PMID 17353931.  
  4. ^ Viollet, B; Lefrançois-Martinez A M, Henrion A, Kahn A, Raymondjean M, Martinez A (Jan. 1996). "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms". J. Biol. Chem. (UNITED STATES) 271 (3): 1405–15. ISSN 0021-9258. PMID 8576131.  
  5. ^ Moore, Meredith L; Park Edwards A, McMillin Jeanie B (May. 2003). "Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1". J. Biol. Chem. (United States) 278 (19): 17263–8. doi:10.1074/jbc.M210486200. ISSN 0021-9258. PMID 12611894.  
  6. ^ Cable, P LouAnn; Wilson Cindy A, Calzone Frank J, Rauscher Frank J, Scully Ralph, Livingston David M, Li Leping, Blackwell Courtney B, Futreal P Andrew, Afshari Cynthia A (Oct. 2003). "Novel consensus DNA-binding sequence for BRCA1 protein complexes". Mol. Carcinog. (United States) 38 (2): 85–96. doi:10.1002/mc.10148. ISSN 0899-1987. PMID 14502648.  

Further reading

  • Corre S, Galibert MD (2006). "[USF as a key regulatory element of gene expression]". Med Sci (Paris) 22 (1): 62–7. PMID 16386222.  
  • Sirito M, Walker S, Lin Q, et al. (1993). "Members of the USF family of helix-loop-helix proteins bind DNA as homo- as well as heterodimers.". Gene Expr. 2 (3): 231–40. PMID 1450663.  
  • Blanar MA, Rutter WJ (1992). "Interaction cloning: identification of a helix-loop-helix zipper protein that interacts with c-Fos.". Science 256 (5059): 1014–8. doi:10.1126/science.1589769. PMID 1589769.  
  • Viollet B, Lefrançois-Martinez AM, Henrion A, et al. (1996). "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms.". J. Biol. Chem. 271 (3): 1405–15. doi:10.1074/jbc.271.3.1405. PMID 8576131.  
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.  
  • Ghosh AK, Datta PK, Jacob ST (1997). "The dual role of helix-loop--helix-zipper protein USF in ribosomal RNA gene transcription in vivo.". Oncogene 14 (5): 589–94. doi:10.1038/sj.onc.1200866. PMID 9053857.  
  • Kurschner C, Morgan JI (1997). "USF2/FIP associates with the b-Zip transcription factor, c-Maf, via its bHLH domain and inhibits c-Maf DNA binding activity.". Biochem. Biophys. Res. Commun. 231 (2): 333–9. doi:10.1006/bbrc.1997.6097. PMID 9070273.  
  • Breen GA, Jordan EM (1997). "Regulation of the nuclear gene that encodes the alpha-subunit of the mitochondrial F0F1-ATP synthase complex. Activation by upstream stimulatory factor 2.". J. Biol. Chem. 272 (16): 10538–42. doi:10.1074/jbc.272.16.10538. PMID 9099698.  
  • Nechushtan H, Zhang Z, Razin E (1997). "Microphthalmia (mi) in murine mast cells: regulation of its stimuli-mediated expression on the translational level.". Blood 89 (8): 2999–3008. PMID 9108421.  
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.  
  • Breen GA, Jordan EM (1999). "Transcriptional activation of the F(1)F(0) ATP synthase alpha-subunit initiator element by USF2 is mediated by p300.". Biochim. Biophys. Acta 1428 (2-3): 169–76. PMID 10434034.  
  • Kumari D, Usdin K (2001). "Interaction of the transcription factors USF1, USF2, and alpha -Pal/Nrf-1 with the FMR1 promoter. Implications for Fragile X mental retardation syndrome.". J. Biol. Chem. 276 (6): 4357–64. doi:10.1074/jbc.M009629200. PMID 11058604.  
  • Kolonics A, Apáti A, Nahajevszky S, et al. (2002). "Unregulated activation of STAT-5, ERK1/2 and c-Fos may contribute to the phenotypic transformation from myelodysplastic syndrome to acute leukaemia.". Haematologia (Budap) 31 (2): 125–38. doi:10.1163/15685590152492936. PMID 11583024.  
  • Bengtsson SH, Madeyski-Bengtson K, Nilsson J, Bjursell G (2002). "Transcriptional regulation of the human carboxyl ester lipase gene in THP-1 monocytes: an E-box required for activation binds upstream stimulatory factors 1 and 2.". Biochem. J. 365 (Pt 2): 481–8. doi:10.1042/BJ20020223. PMID 11945176.  
  • Villavicencio EH, Yoon JW, Frank DJ, et al. (2002). "Cooperative E-box regulation of human GLI1 by TWIST and USF.". Genesis 32 (4): 247–58. doi:10.1002/gene.10078. PMID 11948912.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Moore ML, Park EA, McMillin JB (2003). "Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1.". J. Biol. Chem. 278 (19): 17263–8. doi:10.1074/jbc.M210486200. PMID 12611894.  
  • Pickwell GV, Shih H, Quattrochi LC (2003). "Interaction of upstream stimulatory factor proteins with an E-box located within the human CYP1A2 5'-flanking gene contributes to basal transcriptional gene activation.". Biochem. Pharmacol. 65 (7): 1087–96. doi:10.1016/S0006-2952(03)00037-6. PMID 12663044.  
  • Zhu J, Giannola DM, Zhang Y, et al. (2003). "NF-Y cooperates with USF1/2 to induce the hematopoietic expression of HOXB4.". Blood 102 (7): 2420–7. doi:10.1182/blood-2003-01-0251. PMID 12791656.  


Got something to say? Make a comment.
Your name
Your email address