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Uramustine: Wikis


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Systematic (IUPAC) name
CAS number 66-75-1
ATC code none
PubChem 6194
DrugBank APRD00130
Chemical data
Formula C 8H11Cl2N3O2  
Mol. mass 252.097 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 5%
Metabolism  ?
Half life  ?
Excretion Renal
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?
 Yes check.svgY(what is this?)  (verify)

Uramustine (INN) or uracil mustard is a chemotherapy drug which belongs to the class of alkylating agents. It is used in lymphatic malignancies such as non-Hodgkin's lymphoma. It works by damaging DNA, primarily in cancer cells that preferentially take up the uracil due to their need to make nucleic acids during their rapid cycles of cell division. The DNA damage leads to apoptosis of the affected cells. Bone marrow suppression and nausea are the main side effects.

Chemically it is a derivative of nitrogen mustard and uracil.



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