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Bethanechol
Systematic (IUPAC) name
2-(carbamoyloxy)- N,N,N-trimethylpropan- 1-aminium
Identifiers
CAS number 674-38-4
ATC code N07AB02
PubChem 2370
DrugBank APRD00051
ChemSpider 2280
Chemical data
Formula C 7H17N2O2  
Mol. mass 161.221 g/mol
SMILES eMolecules & PubChem
Synonyms 2-[(aminocarbonyl)oxy]- N,N,N-trimethyl- 1-propanaminium
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat. C(US)
Legal status
Routes Oral, subcutaneous
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Bethanechol is a parasympathomimetic choline ester that selectively stimulates muscarinic receptors (with further selectivity for M3 receptors) without any effect on nicotinic receptors. Unlike acetylcholine, bethanechol is not hydrolyzed by cholinesterase and will therefore have a long duration of action.

Bethanechol is sold under the brand names Duvoid (Roberts), Myotonachol (Glenwood), and Urecholine (Merck Frosst).

Uses

Bethanechol is sometimes given orally or subcutaneously to treat urinary retention resulting from general anesthetic or diabetic neuropathy of the bladder, or to treat gastrointestinal atony (lack of muscular tone). The muscarinic receptors in the bladder and gastrointestinal tract stimulate contraction of the bladder and expulsion of urine, and increased gastrointestinal motility, respectively. Bethanechol should be used to treat these disorders only after obstruction is ruled out as a possible cause.

Its potential benefit in the treatment of cerebral palsy has been investigated.[1]

Contraindictions

Use of bethanechol, as well as all other muscarinic receptor agonists, is contraindicated in patients with asthma, coronary insufficiency, peptic ulcers, and hyperthyroidism. The parasympathomimetic action of this drug will exacerbate the symptoms of these disorders.

References

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