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V-erbA-related gene: Wikis

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Nuclear receptor subfamily 2, group F, member 6
Identifiers
Symbols NR2F6; EAR-2; EAR2; ERBAL2
External IDs OMIM132880 MGI1352453 HomoloGene7706 GeneCards: NR2F6 Gene
RNA expression pattern
PBB GE NR2F6 209262 s at tn.png
PBB GE NR2F6 209261 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2063 13864
Ensembl ENSG00000160113 ENSMUSG00000002393
UniProt P10588 Q3UIT0
RefSeq (mRNA) NM_005234 NM_010150
RefSeq (protein) NP_005225 NP_034280
Location (UCSC) Chr 19:
17.2 - 17.22 Mb
Chr 8:
74.3 - 74.31 Mb
PubMed search [1] [2]

The protein encoded by the v-erbA-related gene (ear-2) (also known as NR2F6, nuclear receptor subfamily 2, group F, member 6) is a member of the nuclear receptor family of intracellular transcription factors.[1]

Comparatively little is known about ear-2, but is has been shown to function as a coregulator of other nuclear receptors.[2][3]

Nr2f6 knockout mice show defects in development of the locus ceruleus.[4]

Contents

Interactions

V-erbA-related gene has been shown to interact with Thyroid hormone receptor beta[2] and COUP-TFII.[5]

References

  1. ^ Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, Matsubara K, Toyoshima K, Yamamoto T (1988). "Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other". Nucleic Acids Res. 16 (23): 11057–74. doi:10.1093/nar/16.23.11057. PMID 2905047.  
  2. ^ a b Zhu XG, Park KS, Kaneshige M, Bhat MK, Zhu Q, Mariash CN, McPhie P, Cheng SY (2000). "The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function". Mol. Cell. Biol. 20 (7): 2604–18. doi:10.1128/MCB.20.7.2604-2618.2000. PMID 10713182.  
  3. ^ Liu X, Huang X, Sigmund CD (2003). "Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription". Circ. Res. 92 (9): 1033–40. doi:10.1161/01.RES.0000071355.82009.43. PMID 12690040.  
  4. ^ Warnecke M, Oster H, Revelli JP, Alvarez-Bolado G, Eichele G (March 2005). "Abnormal development of the locus coeruleus in Ear2(Nr2f6)-deficient mice impairs the functionality of the forebrain clock and affects nociception". Genes Dev. 19 (5): 614–25. doi:10.1101/gad.317905. PMID 15741322.  
  5. ^ Avram, D; Ishmael J E, Nevrivy D J, Peterson V J, Lee S H, Dowell P, Leid M (May. 1999). "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2". J. Biol. Chem. (UNITED STATES) 274 (20): 14331–6. ISSN 0021-9258. PMID 10318855.  

Further reading

  • Miyajima N, Kadowaki Y, Fukushige S, et al. (1989). "Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other.". Nucleic Acids Res. 16 (23): 11057–74. doi:10.1093/nar/16.23.11057. PMID 2905047.  
  • Bähler M, Kehrer I, Gordon L, et al. (1997). "Physical mapping of human myosin-IXB (MYO9B), the human orthologue of the rat myosin myr 5, to chromosome 19p13.1.". Genomics 43 (1): 107–9. doi:10.1006/geno.1997.4776. PMID 9226381.  
  • Avram D, Ishmael JE, Nevrivy DJ, et al. (1999). "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2.". J. Biol. Chem. 274 (20): 14331–6. doi:10.1074/jbc.274.20.14331. PMID 10318855.  
  • Zhang Y, Dufau ML (2000). "Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor.". J. Biol. Chem. 275 (4): 2763–70. doi:10.1074/jbc.275.4.2763. PMID 10644740.  
  • Zhu XG, Park KS, Kaneshige M, et al. (2000). "The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function.". Mol. Cell. Biol. 20 (7): 2604–18. doi:10.1128/MCB.20.7.2604-2618.2000. PMID 10713182.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Liu X, Huang X, Sigmund CD (2003). "Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription.". Circ. Res. 92 (9): 1033–40. doi:10.1161/01.RES.0000071355.82009.43. PMID 12690040.  
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  

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