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Ventral anterior homeobox 1
Symbols VAX1; MGC126743; MGC126745
External IDs OMIM604294 MGI1277163 HomoloGene7593 GeneCards: VAX1 Gene
Species Human Mouse
Entrez 11023 22326
Ensembl ENSG00000148704 ENSMUSG00000006270
UniProt Q5SQQ9 Q2NKI2
RefSeq (mRNA) NM_199131 XM_976050
RefSeq (protein) NP_954582 XP_981144
Location (UCSC) Chr 10:
118.88 - 118.89 Mb
Chr 19:
59.22 - 59.22 Mb
PubMed search [1] [2]

Ventral anterior homeobox 1 is a protein that in humans is encoded by the VAX1 gene.[1][2][3]

This gene appears to influence the development in humans of the forebrain. It is also present in mice and xenopus frogs, which suggests a long evolutionary history, and in those organisms its expression is confined to the forebrain, optic and olfactory areas.[4]


  1. ^ Hallonet M, Hollemann T, Wehr R, Jenkins NA, Copeland NG, Pieler T, Gruss P (Aug 1998). "Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain". Development 125 (14): 2599-610. PMID 9636075.  
  2. ^ Barbieri AM, Lupo G, Bulfone A, Andreazzoli M, Mariani M, Fougerousse F, Consalez GG, Borsani G, Beckmann JS, Barsacchi G, Ballabio A, Banfi S (Oct 1999). "A homeobox gene, vax2, controls the patterning of the eye dorsoventral axis". Proc Natl Acad Sci U S A 96 (19): 10729-34. PMID 10485894.  
  3. ^ "Entrez Gene: VAX1 ventral anterior homeobox 1".  
  4. ^ *Hallonet M, Hollemann T, Wehr R, et al. (1998). "Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain.". Development 125 (14): 2599–610. PMID 9636075.   pdf

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  


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