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Voltage-dependent anion channel 1
Symbols VDAC1; MGC111064; PORIN; PORIN-31-HL
External IDs OMIM604492 MGI106919 HomoloGene36115 GeneCards: VDAC1 Gene
RNA expression pattern
PBB GE VDAC1 212038 s at tn.png
PBB GE VDAC1 217140 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7416 22333
Ensembl ENSG00000073905 ENSMUSG00000020402
UniProt P21796 Q3THL7
RefSeq (mRNA) NM_003374 NM_011694
RefSeq (protein) NP_003365 NP_035824
Location (UCSC) Chr 5:
133.34 - 133.37 Mb
Chr 11:
52.2 - 52.23 Mb
PubMed search [1] [2]

Voltage-dependent anion-selective channel protein 1 is a protein that in humans is encoded by the VDAC1 gene.[1][2]


See also


VDAC1 has been shown to interact with Gelsolin,[3] BCL2-like 1,[4][5][6][7] PRKCE,[8] Bcl-2-associated X protein[4][5] and DYNLT3.[9]


  1. ^ Blachly-Dyson E, Baldini A, Litt M, McCabe ER, Forte M (Jul 1994). "Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: mapping and identification of two new isoforms". Genomics 20 (1): 62–7. doi:10.1006/geno.1994.1127. PMID 7517385.  
  2. ^ "Entrez Gene: VDAC1 voltage-dependent anion channel 1".  
  3. ^ Kusano, H; Shimizu S, Koya R C, Fujita H, Kamada S, Kuzumaki N, Tsujimoto Y (Oct. 2000). "Human gelsolin prevents apoptosis by inhibiting apoptotic mitochondrial changes via closing VDAC". Oncogene (ENGLAND) 19 (42): 4807–14. doi:10.1038/sj.onc.1203868. ISSN 0950-9232. PMID 11039896.  
  4. ^ a b Weng, Changjiang; Li Yuan, Xu Dan, Shi Yong, Tang Hong (Mar. 2005). "Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells". J. Biol. Chem. (United States) 280 (11): 10491–500. doi:10.1074/jbc.M412819200. ISSN 0021-9258. PMID 15637055.  
  5. ^ a b Shi, Yong; Chen Jianjun, Weng Changjiang, Chen Rui, Zheng Yanhua, Chen Quan, Tang Hong (Jun. 2003). "Identification of the protein-protein contact site and interaction mode of human VDAC1 with Bcl-2 family proteins". Biochem. Biophys. Res. Commun. (United States) 305 (4): 989–96. ISSN 0006-291X. PMID 12767928.  
  6. ^ Shimizu, S; Konishi A, Kodama T, Tsujimoto Y (Mar. 2000). "BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (7): 3100–5. ISSN 0027-8424. PMID 10737788.  
  7. ^ Shimizu, S; Narita M, Tsujimoto Y (Jun. 1999). "Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC". Nature (ENGLAND) 399 (6735): 483–7. doi:10.1038/20959. ISSN 0028-0836. PMID 10365950.  
  8. ^ Baines, Christopher P; Song Chang-Xu, Zheng Yu-Ting, Wang Guang-Wu, Zhang Jun, Wang Ou-Li, Guo Yiru, Bolli Roberto, Cardwell Ernest M, Ping Peipei (May. 2003). "Protein kinase Cepsilon interacts with and inhibits the permeability transition pore in cardiac mitochondria". Circ. Res. (United States) 92 (8): 873–80. doi:10.1161/01.RES.0000069215.36389.8D. PMID 12663490.  
  9. ^ Schwarzer, Christian; Barnikol-Watanabe Shitsu, Thinnes Friedrich P, Hilschmann Norbert (Sep. 2002). "Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74". Int. J. Biochem. Cell Biol. (England) 34 (9): 1059–70. ISSN 1357-2725. PMID 12009301.  

Further reading

  • Verrier F, Mignotte B, Jan G, Brenner C (2004). "Study of PTPC composition during apoptosis for identification of viral protein target.". Ann. N. Y. Acad. Sci. 1010: 126–42. doi:10.1196/annals.1299.022. PMID 15033708.  
  • McEnery MW, Snowman AM, Trifiletti RR, Snyder SH (1992). "Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier.". Proc. Natl. Acad. Sci. U.S.A. 89 (8): 3170–4. doi:10.1073/pnas.89.8.3170. PMID 1373486.  
  • Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.  
  • Jürgens L, Ilsemann P, Kratzin HD, et al. (1991). "Studies on human porin. IV. The primary structures of "Porin 31HM" purified from human skeletal muscle membranes and of "Porin 31HL" derived from human B lymphocyte membranes are identical.". Biol. Chem. Hoppe-Seyler 372 (7): 455–63. PMID 1657034.  
  • Kayser H, Kratzin HD, Thinnes FP, et al. (1990). "[Identification of human porins. II. Characterization and primary structure of a 31-lDa porin from human B lymphocytes (Porin 31HL).]". Biol. Chem. Hoppe-Seyler 370 (12): 1265–78. PMID 2559745.  
  • Brdiczka D, Kaldis P, Wallimann T (1994). "In vitro complex formation between the octamer of mitochondrial creatine kinase and porin.". J. Biol. Chem. 269 (44): 27640–4. PMID 7525559.  
  • Yu WH, Wolfgang W, Forte M (1995). "Subcellular localization of human voltage-dependent anion channel isoforms.". J. Biol. Chem. 270 (23): 13998–4006. doi:10.1074/jbc.270.23.13998. PMID 7539795.  
  • Thomas L, Blachly-Dyson E, Colombini M, Forte M (1993). "Mapping of residues forming the voltage sensor of the voltage-dependent anion-selective channel.". Proc. Natl. Acad. Sci. U.S.A. 90 (12): 5446–9. doi:10.1073/pnas.90.12.5446. PMID 7685903.  
  • Blachly-Dyson E, Zambronicz EB, Yu WH, et al. (1993). "Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel.". J. Biol. Chem. 268 (3): 1835–41. PMID 8420959.  
  • Schleiff E, Shore GC, Goping IS (1997). "Human mitochondrial import receptor, Tom20p. Use of glutathione to reveal specific interactions between Tom20-glutathione S-transferase and mitochondrial precursor proteins.". FEBS Lett. 404 (2-3): 314–8. doi:10.1016/S0014-5793(97)00145-2. PMID 9119086.  
  • Reymann S, Haase W, Krick W, et al. (1998). "Endosomes: another extra-mitochondrial location of type-1 porin/voltage-dependent anion-selective channels.". Pflugers Arch. 436 (3): 478–80. doi:10.1007/s004240050659. PMID 9644232.  
  • Narita M, Shimizu S, Ito T, et al. (1999). "Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria.". Proc. Natl. Acad. Sci. U.S.A. 95 (25): 14681–6. doi:10.1073/pnas.95.25.14681. PMID 9843949.  
  • Crompton M, Virji S, Ward JM (1999). "Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore.". Eur. J. Biochem. 258 (2): 729–35. doi:10.1046/j.1432-1327.1998.2580729.x. PMID 9874241.  
  • Messina A, Oliva M, Rosato C, et al. (1999). "Mapping of the human Voltage-Dependent Anion Channel isoforms 1 and 2 reconsidered.". Biochem. Biophys. Res. Commun. 255 (3): 707–10. doi:10.1006/bbrc.1998.0136. PMID 10049775.  
  • Shimizu S, Narita M, Tsujimoto Y (1999). "Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC.". Nature 399 (6735): 483–7. doi:10.1038/20959. PMID 10365962.  
  • Decker WK, Bowles KR, Schatte EC, et al. (2000). "Revised fine mapping of the human voltage-dependent anion channel loci by radiation hybrid analysis.". Mamm. Genome 10 (10): 1041–2. doi:10.1007/s003359901158. PMID 10501981.  
  • Jacotot E, Ravagnan L, Loeffler M, et al. (2000). "The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore.". J. Exp. Med. 191 (1): 33–46. doi:10.1084/jem.191.1.33. PMID 10620603.  
  • Shimizu S, Tsujimoto Y (2000). "Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity.". Proc. Natl. Acad. Sci. U.S.A. 97 (2): 577–82. doi:10.1073/pnas.97.2.577. PMID 10639121.  
  • Stadtmüller U, Eben-Brunnen J, Schmid A, et al. (2000). "Mitochondria-derived and extra-mitochondrial human type-1 porin are identical as revealed by amino acid sequencing and electrophysiological characterisation.". Biol. Chem. 380 (12): 1461–6. doi:10.1515/BC.1999.189. PMID 10661876.  

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