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voltage-dependent anion channel 2
Symbols VDAC2; FLJ23841
External IDs OMIM193245 MGI106915 HomoloGene37765 GeneCards: VDAC2 Gene
Species Human Mouse
Entrez 7417 22334
Ensembl ENSG00000165637 ENSMUSG00000021771
UniProt P45880 Q60930
RefSeq (mRNA) NM_003375 NM_011695
RefSeq (protein) NP_003366 NP_035825
Location (UCSC) Chr 10:
76.64 - 76.66 Mb
Chr 14:
22.65 - 22.66 Mb
PubMed search [1] [2]

Voltage-dependent anion-selective channel protein 2 is a protein that in humans is encoded by the VDAC2 gene.[1][2] The protein encoded by this gene is a voltage-dependent anion channel.[1][2]

VDAC2 is involved in the regulation of mitochondrial apoptosis.[3]


  1. ^ a b Blachly-Dyson E, Baldini A, Litt M, McCabe ER, Forte M (Jul 1994). "Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: mapping and identification of two new isoforms". Genomics 20 (1): 62-7. doi:10.1006/geno.1994.1127. PMID 7517385.  
  2. ^ a b Messina A, Oliva M, Rosato C, Huizing M, Ruitenbeek W, van den Heuvel LP, Forte M, Rocchi M, De Pinto V (Apr 1999). "Mapping of the human Voltage-Dependent Anion Channel isoforms 1 and 2 reconsidered". Biochem Biophys Res Commun 255 (3): 707-10. doi:10.1006/bbrc.1998.0136. PMID 10049775.  
  3. ^ Cheng EH, Sheiko TV, Fisher JK, Craigen WJ, Korsmeyer SJ (July 2003). "VDAC2 inhibits BAK activation and mitochondrial apoptosis". Science (journal) 301 (5632): 513–7. doi:10.1126/science.1083995. PMID 12881569.  

Further reading

  • Blachly-Dyson E, Zambronicz EB, Yu WH, et al. (1993). "Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel.". J. Biol. Chem. 268 (3): 1835-41. PMID 8420959.  
  • Valis K, Neubauerova J, Man P, et al. (2008). "VDAC2 and aldolase A identified as membrane proteins of K562 cells with increased expression under iron deprivation.". Mol. Cell. Biochem. 311 (1-2): 225-31. doi:10.1007/s11010-008-9712-x. PMID 18278581.  
  • Mannella CA (1998). "Conformational changes in the mitochondrial channel protein, VDAC, and their functional implications.". J. Struct. Biol. 121 (2): 207-18. doi:10.1006/jsbi.1997.3954. PMID 9615439.  
  • Bogenhagen DF, Rousseau D, Burke S (2008). "The layered structure of human mitochondrial DNA nucleoids.". J. Biol. Chem. 283 (6): 3665-75. doi:10.1074/jbc.M708444200. PMID 18063578.  
  • Chandra D, Choy G, Daniel PT, Tang DG (2005). "Bax-dependent regulation of Bak by voltage-dependent anion channel 2.". J. Biol. Chem. 280 (19): 19051-61. doi:10.1074/jbc.M501391200. PMID 15757910.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  
  • Yoo BC, Fountoulakis M, Cairns N, Lubec G (2001). "Changes of voltage-dependent anion-selective channel proteins VDAC1 and VDAC2 brain levels in patients with Alzheimer's disease and Down syndrome.". Electrophoresis 22 (1): 172-9. doi:10.1002/1522-2683(200101)22:1<172::AID-ELPS172>3.0.CO;2-P. PMID 11197169.  
  • Ahmed M, Forsberg J, Bergsten P. "Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry.". J. Proteome Res. 4 (3): 931-40. doi:10.1021/pr050024a. PMID 15952740.  
  • Ha H, Hajek P, Bedwell DM, Burrows PD (1993). "A mitochondrial porin cDNA predicts the existence of multiple human porins.". J. Biol. Chem. 268 (16): 12143-9. PMID 7685033.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Yu WH, Wolfgang W, Forte M (1995). "Subcellular localization of human voltage-dependent anion channel isoforms.". J. Biol. Chem. 270 (23): 13998-4006. PMID 7539795.  
  • Hinsch KD, De Pinto V, Aires VA, et al. (2004). "Voltage-dependent anion-selective channels VDAC2 and VDAC3 are abundant proteins in bovine outer dense fibers, a cytoskeletal component of the sperm flagellum.". J. Biol. Chem. 279 (15): 15281-8. doi:10.1074/jbc.M313433200. PMID 14739283.  
  • Decker WK, Bowles KR, Schatte EC, et al. (1999). "Revised fine mapping of the human voltage-dependent anion channel loci by radiation hybrid analysis.". Mamm. Genome 10 (10): 1041-2. PMID 10501981.  
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77-83. doi:10.1038/nature03207. PMID 15635413.  
  • Bernhard OK, Cunningham AL, Sheil MM (2004). "Analysis of proteins copurifying with the CD4/lck complex using one-dimensional polyacrylamide gel electrophoresis and mass spectrometry: comparison with affinity-tag based protein detection and evaluation of different solubilization methods.". J. Am. Soc. Mass Spectrom. 15 (4): 558-67. doi:10.1016/j.jasms.2003.12.006. PMID 15047060.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375-81. doi:10.1038/nature02462. PMID 15164054.  
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.  

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