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voltage-dependent anion channel 3
Symbol VDAC3
External IDs OMIM610029 MGI106922 HomoloGene36115 GeneCards: VDAC3 Gene
Species Human Mouse
Entrez 7419 22335
Ensembl ENSG00000078668 ENSMUSG00000008892
UniProt Q9Y277 Q60931
RefSeq (mRNA) NM_001135694 NM_011696
RefSeq (protein) NP_005653 NP_035826
Location (UCSC) Chr 8:
42.37 - 42.38 Mb
Chr 8:
23.69 - 23.7 Mb
PubMed search [1] [2]

Voltage-dependent anion-selective channel protein 3 is a protein that in humans is encoded by the VDAC3 gene. [1] [2]

VDAC3 orthologs [3] have been identified in most mammals for which complete genome data are available.

The protein encoded by this gene is a voltage-dependent anion channel.[1][2]


  1. ^ a b Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Aug 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc Natl Acad Sci U S A 95 (14): 8175-80. PMID 9653160.  
  2. ^ a b Rahmani Z, Maunoury C, Siddiqui A (Nov 1998). "Isolation of a novel human voltage-dependent anion channel gene". Eur J Hum Genet 6 (4): 337-40. doi:10.1038/sj.ejhg.5200198. PMID 9781040.  
  3. ^ "OrthoMaM phylogenetic marker: VDAC3 coding sequence".  

Further reading

  • .  
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.  
  • Lefièvre L, Chen Y, Conner SJ, et al. (2007). "Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide?". Proteomics 7 (17): 3066-84. doi:10.1002/pmic.200700254. PMID 17683036.  
  • Decker WK, Craigen WJ (2000). "The tissue-specific, alternatively spliced single ATG exon of the type 3 voltage-dependent anion channel gene does not create a truncated protein isoform in vivo.". Mol. Genet. Metab. 70 (1): 69-74. doi:10.1006/mgme.2000.2987. PMID 10833333.  
  • Sampson MJ, Decker WK, Beaudet AL, et al. (2001). "Immotile sperm and infertility in mice lacking mitochondrial voltage-dependent anion channel type 3.". J. Biol. Chem. 276 (42): 39206-12. doi:10.1074/jbc.M104724200. PMID 11507092.  
  • Sampson MJ, Lovell RS, Craigen WJ (1997). "The murine voltage-dependent anion channel gene family. Conserved structure and function.". J. Biol. Chem. 272 (30): 18966-73. PMID 9228078.  
  • Zhang QH, Ye M, Wu XY, et al. (2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546-60. PMID 11042152.  
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.  
  • Hinsch KD, De Pinto V, Aires VA, et al. (2004). "Voltage-dependent anion-selective channels VDAC2 and VDAC3 are abundant proteins in bovine outer dense fibers, a cytoskeletal component of the sperm flagellum.". J. Biol. Chem. 279 (15): 15281-8. doi:10.1074/jbc.M313433200. PMID 14739283.  
  • Decker WK, Bowles KR, Schatte EC, et al. (1999). "Revised fine mapping of the human voltage-dependent anion channel loci by radiation hybrid analysis.". Mamm. Genome 10 (10): 1041-2. PMID 10501981.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94-101. doi:10.1038/nbt1046. PMID 15592455.  
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.  
  • Sampson MJ, Ross L, Decker WK, Craigen WJ (1998). "A novel isoform of the mitochondrial outer membrane protein VDAC3 via alternative splicing of a 3-base exon. Functional characteristics and subcellular localization.". J. Biol. Chem. 273 (46): 30482-6. PMID 9804816.  
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.  

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