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(Redirected to Vesicular monoamine transporter article)

From Wikipedia, the free encyclopedia

The vesicular monoamine transporter (aka VMAT) is a transport protein integrated into the membrane of intracellular vesicles of presynaptic neurons. It acts to transport monoamines into the synaptic vesicles.

Contents

Isoforms

The two isoforms are:

Substrates

Substrates for the transporter are mainly noradrenaline, adrenaline and isoprenaline. However, other substrates include dopamine, 5-HT, guanethidine and MPP+.[1]

Clinical significance

VMAT can be inhibited by reserpine and tetrabenazine.[1]

VMAT is the main target of methamphetamine. By acting as a competitive antagonist, methamphetamine blocks the presynaptic cell's ability to use VMAT to package the above mentioned neurotransmitters into vesicles. The result is increased neurotransimtter release that is not dependent on the phasic activity of the presynaptic cell.

References

  1. ^ a b Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4.   Page 167

Further reading

External links

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