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VUF-5681: Wikis

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VUF-5681
VUF-5681.png
IUPAC name
Identifiers
CAS number 768358-61-8
SMILES
Properties
Molecular formula C11H19N3
Molar mass 193.288
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

VUF-5681 is a potent and selective histamine antagonist which binds selectively to the H3 subtype.[1] However while VUF-5681 blocks the activity of more potent H3 agonists, recent studies suggest that it may have some weak partial agonist activity when administered by itself.[2]

References

  1. ^ Moreno-Delgado D, Torrent A, Gómez-Ramírez J, de Esch I, Blanco I, Ortiz J. Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway. Neuropharmacology. 2006 Sep;51(3):517-23. PMID 16769092
  2. ^ Baker JG. Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells. BMC Pharmacology. 2008 Jun 6;8:9. PMID 18538007
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