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VUF-6002: Wikis


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Systematic (IUPAC) name
5-Chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1 H-benzimidazole
CAS number 869497-75-6
ATC code  ?
PubChem 10446295
Chemical data
Formula C 13H15ClN4O 
Mol. mass 278.737 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

VUF-6002 (JNJ 10191584) is a drug which acts as a potent and selective antagonist at the histamine H4 receptor.[1] It has antiinflammatory and analgesic effects in animal studies of acute inflammation.[2]


  1. ^ Zhang M, Thurmond RL, Dunford PJ. The histamine H(4) receptor: a novel modulator of inflammatory and immune disorders. Pharmacology and Therapeutics. 2007 Mar;113(3):594-606. PMID 17275092
  2. ^ Coruzzi G, Adami M, Guaita E, de Esch IJ, Leurs R. Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation. European Journal of Pharmacology. 2007 Jun 1;563(1-3):240-4. PMID 17382315


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