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Vasoactive intestinal peptide receptor: Wikis


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vasoactive intestinal peptide receptor 1
Symbol VIPR1
Alt. symbols RDC1, HVR1, VAPC1
Entrez 7433
HUGO 12694
OMIM 192321
RefSeq NM_004624
UniProt P32241
Other data
Locus Chr. 3 p22
vasoactive intestinal peptide receptor 2
Symbol VIPR2
Alt. symbols VPAC2
Entrez 7434
HUGO 12695
OMIM 601970
RefSeq NM_003382
UniProt P41587
Other data
Locus Chr. 7 q36.3
adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
Symbol ADCYAP1R1
Alt. symbols PACAPR
Entrez 117
HUGO 242
OMIM 102981
RefSeq NM_001118
UniProt P41586
Other data
Locus Chr. 7 p14

There are two known receptors for the vasoactive intestinal peptide (VIP) termed VPAC1 and VPAC2.[1][2] These receptors bind both VIP and pituitary adenylate cyclase-activating polypeptide (PACAP) to some degree. Both receptors are members of the 7 transmembrane G-protein coupled receptor family.

VPAC1 is distributed widely in the CNS, liver, lung, intestine and T-lymphocytes.

VPAC2 is found in the CNS, pancreas, skeletal muscle, heart, kidney, adipose tissue, testis, and stomach.


  1. ^ Laburthe M, Couvineau A, Marie JC (2002). "VPAC receptors for VIP and PACAP". Recept. Channels 8 (3-4): 137–53. doi:10.1080/10606820213680. PMID 12529932.  
  2. ^ Laburthe M, Couvineau A (2002). "Molecular pharmacology and structure of VPAC Receptors for VIP and PACAP". Regul. Pept. 108 (2-3): 165–73. doi:10.1016/S0167-0115(02)00099-X. PMID 12220741.  

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