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Vecuronium: Wikis


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Systematic (IUPAC) name
[(2S,3S,5S,8R,9 S,10S,13S,14S,16S,17S)-
1H-cyclopenta[a]phenanthren-3-yl] acetate
CAS number 50700-72-6
ATC code M03AC03
PubChem 39765
Chemical data
Formula C 34H57N2O4 +
Mol. mass 557.827 g/mol
Pharmacokinetic data
Bioavailability 100% (IV)
Metabolism liver 30%
Half life 51–80 minutes (longer with renal failure)
Excretion Fecal (40-75%) and renal (30% as unchanged drug and metabolites)
Therapeutic considerations
Pregnancy cat. C(US)
Legal status
Routes Intravenous
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Vecuronium (Norcuron) is a muscle relaxant in the category of non-depolarizing blocking agents. Vecuronium bromide is indicated as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Although vecuronium bromide is often thought of as a muscle relaxant, it may be more accurate to classify it as a paralyzing agent. It is commercially available as ampoules containing 4 mg of the drug in powder form which needs to be dissolved in distilled water prior to administration to the patient. In India, vials containing 10 mg of vecuronium bromide are also commercially available, for use in patients undergoing prolonged surgical procedures.


Clinical pharmacology

Vecuronium operates by competing for the cholinergic receptors at the motor end plate thereby exerting its muscle relaxing properties which are used adjunctively to general anesthesia. Under balanced anesthesia, the time to recovery to 25% of control (clinical duration) is approximately 25 to 40 minutes after injection and recovery is usually 95% complete approximately 45 to 65 minutes after injection of intubating dose. The neuromuscular blocking action of vecuronium is slightly enhanced in the presence of potent inhalation anesthetics. If vecuronium is first administered more than 5 minutes after the start of the inhalation of enflurane, isoflurane, or halothane, or when a steady state has been achieved, the intubating dose of vecuronium may be decreased by approximately 15%.

Vecuronium is an aminosteroid.

In the news

In 2001, Japanese nurse Daisuke Mori was reported to murder 10 patients using vecuronium bromide.[1] He was convicted of a murder and was sentenced to life imprisonment.[2]

See also


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