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Vedolizumab: Wikis

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Vedolizumab ?
Monoclonal antibody
Source Humanized
Target Integrin α4β7
Identifiers
CAS number 943609-66-3
ATC code none
PubChem  ?
Chemical data
Formula C 6528H10072N1732O2042S42  
Mol. mass 146.8 kDa
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Vedolizumab is a monoclonal antibody being developed by Millennium Pharmaceuticals, Inc. for the treatment of ulcerative colitis and Crohn's disease.[1] It binds to integrin α4β7 (LPAM-1, lymphocyte Peyer's patch adhesion molecule 1)[1][2]

As of October 2009, vedolizumab is undergoing Phase III trials.[3]

References

  1. ^ a b Statement On A Nonproprietary Name Adopted By The USAN Council - Vedolizumab, American Medical Association.
  2. ^ Soler, D; Chapman, T; Yang, LL; Wyant, T; Egan, R; Fedyk, ER (2009). The binding specificity and selective antagonism of vedolizumab, an anti-alpha4beta7 integrin therapeutic antibody in development for inflammatory bowel diseases. 330. pp. 864-75. doi:10.1124/jpet.109.153973. PMID 19509315.  
  3. ^ ClinicalTrials.gov NCT00790933
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