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Venezuelan hemorrhagic fever: Wikis

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Venezuelan hemorrhagic fever
Virus classification
Group: Group V ((-)ssRNA)
Family: Arenaviridae
Genus: Arenavirus
Species

Guanarito virus

Venezuelan hemorrhagic fever
Classification and external resources
ICD-9 066.2

Venezuelan hemorrhagic fever (VHF) is a zoonotic human illness, first identified in 1989.

Presentation

It causes fever and malaise followed by hemorrhagic manifestations and convulsions.[1] It is fatal in 30% of cases. The disease is endemic to Portuguesa state and Barinas state in Venezuela . This virus requires Biosafety Level Three or Four conditions, the highest ones.

Virus

The causal agent, Guanarito virus, is spread to humans through contact with the excreta of two rodent species: the Short-tailed Cane Mouse (Zygodontomys brevicauda), and Alston's Cotton Rat (Sigmodon alstoni). Human-to-human transmission of the virus has not been observed.

Guanarito virus is a member of the Arenavirus genus of negative single-stranded RNA viruses, and is closely related to a number of other rodent-borne emerging viruses that cause hemorrhagic fever in South America.[2]

References

  1. ^ de Manzione N, Salas RA, Paredes H, et al. (1998). "Venezuelan hemorrhagic fever: clinical and epidemiological studies of 165 cases". Clin. Infect. Dis. 26 (2): 308–13. doi:10.1086/516299. PMID 9502447.  
  2. ^ Arenavirus Fact Sheet, Centers for Disease Control.
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