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From Wikipedia, the free encyclopedia

Systematic (IUPAC) name
CAS number 10308-13-1
ATC code none
PubChem 5315204
Chemical data
Formula C 26H29NO5  
Mol. mass 435.512 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Cryogenine is a biphenylquinolizidine lactone alkaloid, also known as vertine or (10α)-4,5-dimethoxy-2-hydroxylythran-12-one, from the plant sinicuichi (Heimia salicifolia and Heimia myrtifolia). The compound has no psychoactive properties in humans up to 310 mg, but has shown anti-inflammatory activity similar to aspirin.[1]

The freebase form melts at 250-251 °C and is soluble in moderately polar organic solvents such as chloroform, methylene chloride, benzene, and methanol, but is insoluble in water and petroleum ether.

In the development of thin layer chromatography plates with diazotized p-nitroaniline spray, vertine produces a purple spot (as does sinicuichine, another biphenylquinolizidine lactone alkaloid found in the Heimias).

See also


  1. ^ Heimia salicifolia: A phytochemical and phytopharmacologic review. M. H. Malone , A. Rother, J. Ethnopharmacol. 42(3):135-159 (1994) PMID 7934084 doi 10.1016/0378-8741(94)90080-9 Erowid references


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