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Vesicular acetylcholine transporter: Wikis


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solute carrier family 18 (vesicular acetylcholine), member 3
Symbol SLC18A3
Entrez 6572
HUGO 10936
OMIM 600336
RefSeq NM_003055
UniProt Q16572
Other data
Locus Chr. 10 q11.2

The Vesicular acetylcholine transporter (VAChT) is a neurotransmitter transporter which is responsible for loading acetylcholine (ACh) into secretory organelles in neurons making acetylcholine available for secretion.[1][2]


VACh uptake inhibitors


Radiolabeled compounds

PET imaging of the VAChT may provide insights into early diagnosis of Alzheimer's disease.

  • (−)-trans-2-Hydroxy-3-(4-(4-[18F]fluorobenzoyl)piperidino)tetralin; racemate: Ki = 2.70 nM for VAChT, 191 nM for σ1, and 251 nM for σ2[3]


  1. ^ Erickson JD, Varoqui H (2000). "Molecular analysis of vesicular amine transporter function and targeting to secretory organelles". Faseb J. 14 (15): 2450–8. doi:10.1096/fj.00-0206rev. PMID 11099462.  
  2. ^ Weihe E, Tao-Cheng JH, Schäfer MK, Erickson JD, Eiden LE (1996). "Visualization of the vesicular acetylcholine transporter in cholinergic nerve terminals and its targeting to a specific population of small synaptic vesicles". Proc. Natl. Acad. Sci. U.S.A. 93 (8): 3547–52. doi:10.1073/pnas.93.8.3547. PMID 8622973.  
  3. ^ Tu Z, Efange SM, Xu J, et al (February 2009). "Synthesis and in Vitro and in Vivo Evaluation of (18)F-Labeled Positron Emission Tomography (PET) Ligands for Imaging the Vesicular Acetylcholine Transporter". J. Med. Chem.. doi:10.1021/jm8012344. PMID 19203271.  

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