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Viminol
Systematic (IUPAC) name
1-[1-(2-chlorobenzyl)- 1H-pyrrol-2-yl]- 2-(di-sec-butylamino) ethanol
Identifiers
CAS number 21363-18-8
ATC code N02BG05
PubChem 65697
Chemical data
Formula C 21H31ClN2O 
Mol. mass 362.94 g/mol
Synonyms Viminol, Dividol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Rx-Only
Routes Oral

Viminol (marketed under the brandname Dividol) is a drug which is an opioid analgesic. It has an unusual chemical structure that is not similar to other opioids.[1][2]

Viminol has both antitussive (cough suppressing) and analgesic (pain reducing) effects. It has six different stereoisomers which have varying properties, with the 2-(R) isomer being a μ-opioid full agonist slightly more potent than morphine, while the 2-(S) isomer is an antagonist.[3] Since vimonol is supplied as a racemic mixture of isomers, the overall effect produces a mixed agonist-antagonist profile similar to that of opioids such as pentazocine, although with somewhat less side effects.[4]

Viminol has similar effects to other opioids, and produces analgesia, sedation and euphoria.

Side Effects

Side effects are similar to other opioids, and can include:

However, since viminol is supplied as a racemic mixture of agonist and antagonist isomers, the abuse potential and respiratory depression tends to be less than that of μ-opioid full agonist drugs.

References

  1. ^ Contri AM. Chromatographic separation of diastereoisomers of aminoalcohol salts and their densitometric determination. (Italian). Il Farmaco. 1981 Apr;36(4):215-22.
  2. ^ Neto JM, Murad JE, Monteiro SS. Psychopharmacological properties of the viminol-p-hydroxybenzoate. Revista Brasileira de Pesquisas Medicas e Biologicas. 1977 Dec;10(6):361-8.
  3. ^ Shook JE, Kallman MJ, Dewey WL. The discriminative stimulus properties of the R2 isomer of viminol. Pharmacology, Biochemistry and Behaviour. 1984 Jan;20(1):59-62.
  4. ^ Cinelli M, Costa V, Ventresca GP, Lodola E. Viminol R2 analgesic activity in patients with postoperative pain: comparison with pentazocine. International Journal of Clinical Pharmacology, Therapy and Toxicology. 1986 May;24(5):232-5.
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