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WAY-100,135: Wikis


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Systematic (IUPAC) name
(S)-N-tert-butyl- 3-(4-(2-methoxyphenyl)- piperazin-1-yl)- 2-phenylpropanamide
CAS number 133025-23-7
ATC code  ?
PubChem 115111
Chemical data
Formula C 24H33N3O2  
Mol. mass 395.536 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

WAY-100,135 is a piperazine drug and research chemical used in scientific studies. It was originally believed to act as a selective 5-HT1A receptor antagonist, but subsequent research demonstrated that it also acts as a partial agonist at the 5-HT1B and 5-HT1D receptors.[1][2]

See also


  1. ^ Cliffe IA, Brightwell CI, Fletcher A, Forster EA, Mansell HL, Reilly Y, Routledge C, White AC. (1993). "(S)-N-tert-butyl- 3-(4-(2-methoxyphenyl)- piperazin-1-yl)- 2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors.". J Med Chem. 36 (10): 1509–1510. PMID 8496920.  
  2. ^ Davidson C, Ho M, Price GW, Jones BJ, Stamford JA. (1997). "(+)-WAY 100135, a partial agonist, at native and recombinant 5-HT1B/1D receptors.". Br J Pharmacol. 121 (4): 737–742. PMID 9208142.  


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