From Wikipedia, the free encyclopedia
Werner Arber (born 3 June 1929) is a Swiss microbiologist
and geneticist. Along
with American researchers Hamilton Smith and
Daniel
Nathans, Werner Arber shared the 1978 Nobel Prize in
Physiology or Medicine for the discovery of restriction endonucleases. Their work would
lead to the development of recombinant DNA technology.
Werner Arber studied chemistry and physics at the Swiss Federal Institute of Technology in Zürich from 1949 to 1953.
Late in 1953 he took an assistantship for electron microscopy at
the University of Geneva, in time left
the electron microscope, went on to research bacteriophages and
write his dissertation on defective lambda prophage mutants. He received his
doctorate in 1958 from the University of Geneva.
Arber then worked at the University of Southern
California in phage genetics with Joe Bertani starting in the
summer of 1958. Late in 1959 he accepted an offer to return to
Geneva at the beginning of 1960, but only after spending "several
very fruitful weeks"[1] at each of the
laboratories of Gunther Stent at University of
California, Berkeley, Joshua Lederberg at Stanford
University and Salvador Luria at the Massachusetts
Institute of Technology.
Back at the University of Geneva, he worked in a laboratory in
the basement of the Physics Institute where he carried out
productive research and hosted "a number of first class graduate
students, postdoctoral fellows and senior scientists."[2] In 1965 he was
promoted to extraordinary professor for molecular genetics at the
University of Geneva. In 1971 he moved to the University
of Basel, after spending a year as a visiting professor in the
Department of Molecular Biology
of the University of California in Berkeley. In Basel, he was one
of the first persons to work in the newly constructed Biozentrum [3], which housed the departments of biophysics,
biochemistry, microbiology, structural biology, cell biology and
pharmacology which was conducive to interdisciplinary research.
He is member of the World Knowledge Dialogue
Scientific Board.
Arber is married and has two daughters.
References
- Konforti, B (Feb 2000).
"History. The servant with the scissors". Nature structural
biology 7 (2): 99–100. doi:10.1038/72469. ISSN 1072-8368. PMID 10655607.
- Raju, Tn (Oct 1999). "The Nobel
chronicles. 1978: Werner Arber (b 1929); Hamilton O Smith (b 1931);
Daniel Nathans (b 1928)". Lancet 354
(9189): 1567. ISSN 0140-6736. PMID 10551539.
- Shampo, Ma; Kyle, Ra (Oct 1995).
"Werner Arber--Nobel laureate". Mayo Clinic proceedings. Mayo
Clinic 70 (10): 945. ISSN 0025-6196. PMID 7564545.
- Kroon, Am (Feb 1979). "The Nobel
Prize for Medicine and Physiology in 1978 (Werner Arber, Daniel
Nathans, Hamilton Smith)". Nederlands tijdschrift voor
geneeskunde 123 (5): 153–6. ISSN 0028-2162. PMID 368662.
- Piekarowicz, A (1979). "Werner
Arber, Daniel Nathans and Hamilton Smith. Nobel prizes for the
studies on DNA restriction enzymes". Postepy biochemii
25 (2): 251–3. ISSN 0032-5422. PMID 388391.
- Berg, K (Dec 1978). "The Nobel
prize in physiology and medicine 1978. Nobel prize to a
controversial research field". Tidsskrift for den Norske
laegeforening : tidsskrift for praktisk medicin, ny
raekke 98 (34-36): 1741–2. ISSN 0029-2001. PMID 725894.
- Desiderio, S; Boyer, S (Nov
1978). "Arber, Smith and Nathans: Nobel Laureates in medicine and
physiology, 1978". The Johns Hopkins medical journal
143 (5): ix-x. ISSN 0021-7263. PMID 364154.
- "The Nobel prizewinners 1978:
medicine. From modest beginnings…". Nature
275 (5682): 689–90. Oct 1978. ISSN 0028-0836. PMID 360075.
- Peterson, Lr; Gerding, Dn (Aug
1978). "Protein binding and antibiotic concentrations".
Lancet 2 (8085): 376. ISSN 0140-6736. PMID 79742.
- Petterson, R (1978). "Nobel
prize laureates in physiology and medicine". Duodecim;
laaketieteellinen aikakauskirja 94 (23):
1466–9. ISSN 0012-7183. PMID 729493.
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