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William Standish Knowles

Born June 1, 1917 (1917-06-01) (age 92)
Taunton, Massachusetts, USA
Nationality United States
Fields Chemistry
Institutions Thomas and Hochwalt Laboratories
Monsanto Company
Alma mater Columbia University
Doctoral advisor Robert Elderfield
Known for Chiral phosphine ligands that proved effective in the enantioselective synthesis of L-DOPA
Notable awards Nobel Prize in Chemistry (2001)

William S. Knowles (born June 1, 1917) is an American chemist. He was born in Taunton, Massachusetts.

He shared the Nobel Prize in Chemistry in 2001 with Ryoji Noyori and K. Barry Sharpless for the development of catalytic asymmetric synthesis, which is a technology relevant to the preparation of many pharmaceuticals. Knowles led a team of researchers that developed chiral phosphine ligands that proved effective in the enantioselective synthesis of L-DOPA.[1][2] Knowles conducted this prize-winning research at Monsanto Company.

He currently resides in St. Louis, Missouri.

References

  1. ^ Vineyard, B. D.; Knowles, W. S.; Sabacky, M. J.; Bachman, G. L.; Weinkauff, D. J. (1977). "Asymmetric Hydrogenation. Rhodium Chiral Bisphosphine Catalyst". Journal of the American Chemical Society 99 (18): 5946–5952. doi:10.1021/ja00460a018.  
  2. ^ Knowles, W. S. (2002). "Asymmetric Hydrogenations (Nobel Lecture)". Angewandte Chemie International Edition 41: 1998–2007. doi:10.1002/1521-3773(20020617)41:12<1998::AID-ANIE1998>3.0.CO;2-8.  

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