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Xylamidine: Wikis

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Xylamidine
Systematic (IUPAC) name
N'-[2-(3-methoxyphenoxy)propyl]-2-(3-methylphenyl)ethanimidamide
Identifiers
CAS number 6443-50-1
ATC code none
PubChem 22951
Chemical data
Formula C 19H24N2O2  
Mol. mass 312.406 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Xylamidine is a drug which acts as an antagonist at the 5HT2A receptor, and to a lesser extent at the 5HT1A receptor. It does not cross the blood brain barrier which makes it useful for blocking peripheral serotonergic responses like cardiovascular[1][2] and gastrointestinal effects,[3] without producing the central effects of 5HT2A blockade such as sedation, or interfering with the central actions of 5HT2A agonists.[4]

References

  1. ^ Fuller RW, Kurz KD, Mason NR, Cohen ML. Antagonism of a peripheral vascular but not an apparently central serotonergic response by xylamidine and BW 501C67. European Journal of Pharmacology. 1986 Jun 5;125(1):71-7. PMID 3732393
  2. ^ Dedeoğlu A, Fisher LA. Central and peripheral injections of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, modify cardiovascular function through different mechanisms. Journal of Pharmacology and Experimental Therapeutics. 1991 Dec;259(3):1027-34. PMID 1762059
  3. ^ Baker BJ, Duggan JP, Barber DJ, Booth DA. Effects of dl-fenfluramine and xylamidine on gastric emptying of maintenance diet in freely feeding rats. European Journal of Pharmacology. 1988 May 20;150(1-2):137-42. PMID 3402534
  4. ^ Dave KD, Quinn JL, Harvey JA, Aloyo VJ. Role of central 5-HT2 receptors in mediating head bobs and body shakes in the rabbit. Pharmacology, Biochemistry and Behaviour. 2004 Mar;77(3):623-9. PMID 15006475
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