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Xylopropamine: Wikis


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Systematic (IUPAC) name
CAS number 14543-76-1
ATC code none
PubChem 26727
Chemical data
Formula C 11H17N 
Mol. mass 163.259 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Xylopropamine (Perhedrin, Esanin), also known as 3,4-dimethylamphetamine, is a stimulant drug of the phenethylamine and amphetamine chemical classes which was developed in the 1950s as an appetite suppressant. It acts as a stimulant, likely via inducing the release of serotonin, norepinephrine, and dopamine.

Xylopropamine was briefly sold as the sulfate salt, but it was not widely marketed. Other related amphetamine derivatives such as 2,4-dimethylamphetamine were also investigated for the same purpose, however these drugs had negative side effects such as high blood pressure and were not very successful, mainly due to the introduction of alternative drugs like phentermine which had similar efficacy but fewer side effects.

Xylopropamine was also reported as having analgesic[1] and anti-inflammatory[2] effects but its side effect profile resulted in it never being further developed for these applications.

See also


  1. ^ HARRIS SC, WORLEY RC. Analgesic properties of xylopropamine. Proceedings of the Society for Experimental Biology and Medicine. 1957 Jun;95(2):212-5.
  2. ^ RANDALL LO, SELITTO JJ, VALDES J. Anti-inflammatory effects of xylopropamine. Archives Internationales de Pharmacodynamie et de Therapie. 1957 Dec 1;113(1-2):233-49.


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